Everything You Need To Know About Cat’s Claw Benefits, Uses & Side Effects

Cat’s Claw, scientifically known as Uncaria tomentosa, is a remarkable vine native to the Amazon rainforest and other parts of Central and South America. This unique plant has been gaining recognition for its potential health benefits and has become a focal point in the world of herbal supplements and alternative medicine.

Cat’s Claw: A Natural Wonder

Cat’s Claw gets its intriguing name from the curved, claw-like thorns that grow along its stems. The medicinal properties of this vine have been appreciated for centuries by indigenous communities who have harnessed its powers to treat various ailments. It’s an extraordinary example of the invaluable knowledge passed down through generations.

The Science Behind Cat’s Claw

Cat’s Claw contains a variety of active compounds, with the most notable being alkaloids, glycosides, and sterols. These compounds are thought to contribute to its medicinal properties. The two most common species of Cat’s Claw are Uncaria tomentosa and Uncaria guianensis. The former is typically preferred for its potential health benefits.

Cat’s Claw is known for its immune-boosting and anti-inflammatory properties, making it a valuable addition to the world of natural remedies. Its immune-enhancing abilities are attributed to its influence on immune cells like T-cells and B-cells.

Cat’s Claw in Indigenous Healing

For centuries, indigenous tribes have recognized the potential healing properties of Cat’s Claw. They used it to treat a variety of health issues, including inflammation, digestive problems, and wounds. Its use in traditional medicine goes back to the Inca civilization.

Cultural and historical uses of Cat’s Claw

Understanding the cultural and historical significance of Cat’s Claw is like peering into a rich tapestry of ancient knowledge. For generations, indigenous communities in the Amazon rainforest have treasured this unique vine for its medicinal potential. Let’s delve into the roots of Cat’s Claw in traditional medicine.

Ancient Wisdom Meets Modern Interest

The indigenous tribes of the Amazon, such as the Asháninka, Aguaruna, and Shipibo, have used Cat’s Claw for centuries. They recognized its versatility, employing it to address a wide array of health issues. From wounds and infections to digestive troubles, Cat’s Claw played a pivotal role in their healing practices.

A Remedy for Inflammation

One of the primary uses of Cat’s Claw in traditional medicine was to combat inflammation. Native Amazonian communities brewed teas or created poultices from the plant to treat joint pain, arthritis, and other inflammatory conditions.

Protection from Evil Spirits

Cat’s Claw wasn’t just a physical remedy; it also had spiritual significance. Tribes believed that the vine could ward off evil spirits and bring protection to those who used it. It was often included in shamanic rituals and cleansing ceremonies.

A Gift from the Inca

The Inca civilization, known for its advanced understanding of herbal medicine, was also well-acquainted with the benefits of Cat’s Claw. They used it to promote general health and well-being. The Inca, like many indigenous groups, recognized the importance of maintaining harmony between humans and the natural world.

Cat’s Claw Today

In modern times, Cat’s Claw has garnered significant attention beyond its traditional use. Its potential health benefits have led to increased research and exploration. As a result, it has become a sought-after herbal supplement for those seeking a more natural approach to wellness.

Spiritual and ceremonial significance of Cat’s Claw

While the contemporary interest in Cat’s Claw often focuses on its potential health benefits, it’s essential to acknowledge the spiritual and ceremonial significance this plant holds in various indigenous cultures. These spiritual connections are a testament to the plant’s deep-rooted place in human history.

A Bridge to the Spirit World

Cat’s Claw is not merely a physical remedy; it plays a crucial role in the spiritual beliefs and practices of indigenous Amazonian tribes. For them, this plant serves as a bridge between the physical and spiritual realms. Shamans and spiritual leaders use Cat’s Claw in rituals, believing it helps them connect with the spirit world.

Cleansing and Protection

In indigenous ceremonies, Cat’s Claw is often employed to cleanse both individuals and spaces of negative energy or entities. It is believed to protect against malevolent spirits and bring harmony and balance to the participants.

Shamanic Journeying

Shamanic journeying, a practice in which individuals enter an altered state of consciousness, is often facilitated by the use of Cat’s Claw. It is thought to aid in these journeys, allowing individuals to explore the spirit world, gain insight, and receive guidance.

A Way of Life

The spiritual use of Cat’s Claw is not confined to isolated rituals but is woven into the daily lives of indigenous communities. It’s a way to maintain a connection with their ancestors, their natural surroundings, and the wisdom of the past.

Cat’s Claw in Modern Context

While Cat’s Claw’s spiritual significance is deeply ingrained in indigenous cultures, it has also found a place in the modern world. Some individuals, seeking to reconnect with nature and explore alternative spiritual practices, have turned to Cat’s Claw for its potential to aid in meditation and shamanic experiences.

cat's claw benefits

What are the potential medicinal benefits of Cat’s Claw?

Cat’s Claw is not just a plant of spiritual and cultural significance; it also boasts a range of potential medicinal benefits that have garnered attention in the world of natural health. Let’s take a closer look at what Cat’s Claw may offer for your well-being.

Immune System Support

One of the most prominent benefits of Cat’s Claw is its potential to boost the immune system. This vine contains compounds that stimulate immune cell activity, helping your body defend against infections and illnesses. Research suggests that Cat’s Claw may be particularly useful for individuals with weakened immune systems.

Anti-Inflammatory Properties

Cat’s Claw has traditionally been used to reduce inflammation and alleviate conditions like arthritis. This anti-inflammatory action is attributed to its ability to inhibit the production of inflammatory substances in the body. If you’re dealing with chronic inflammation, Cat’s Claw may offer some relief.

Antioxidant Effects

Antioxidants are substances that help protect your cells from damage caused by free radicals. Cat’s Claw is rich in antioxidants, which can potentially slow down the aging process and reduce the risk of chronic diseases. It may also have protective effects on the cardiovascular system.

Digestive Health

Cat’s Claw has been used for digestive complaints in traditional medicine. It may help soothe gastrointestinal issues like ulcers and gastritis. The plant’s anti-inflammatory and antioxidant properties contribute to its potential benefits for digestive health.

Pain Relief

In addition to its anti-inflammatory properties, Cat’s Claw may provide relief from various types of pain, including joint pain and muscle aches. Some individuals with conditions like osteoarthritis have reported improvements in their symptoms.

Potential Anti-Cancer Properties

While more research is needed, some studies have suggested that Cat’s Claw may have anti-cancer properties. Its ability to modulate the immune system and act as an antioxidant may contribute to its potential to support cancer treatment.

Mental Well-Being

Cat’s Claw may not only support your physical health but also your mental well-being. Some people have reported reduced stress and anxiety levels when taking Cat’s Claw supplements. This effect is likely due to its ability to reduce inflammation, which can affect mood.

Find the Best Cat’s Claw Products

Thousands of customer reviews are available to help you make the right choice. Embrace the power of nature!

What other herbs work combined with Cat’s Claw?

Combining herbal supplements can often yield synergistic effects, enhancing the benefits of each herb. Cat’s Claw is no exception, and it can be paired with other herbs to address specific health concerns. Let’s explore some complementary herbs that work well with Cat’s Claw.

Echinacea: Known for its immune-boosting properties, Echinacea can complement Cat’s Claw in strengthening the body’s defenses. This combination may be especially helpful during the cold and flu season.

Turmeric: Turmeric‘s anti-inflammatory properties can enhance Cat’s Claw’s effectiveness in managing inflammatory conditions like arthritis. The two herbs together may provide more substantial relief.

Ginger: Ginger is another powerful anti-inflammatory herb. When combined with Cat’s Claw, it can help alleviate joint pain and improve digestive health.

Astragalus: Like Cat’s Claw, Astragalus is known for its immune-boosting effects. Combining these two herbs can create a potent immune support duo.

Milk Thistle: If you’re looking to support your liver health, Cat’s Claw can be paired with Milk Thistle. This combination may help detoxify the liver and protect it from damage.

Valerian Root: For those seeking relief from anxiety and stress, Cat’s Claw can be used alongside Valerian Root. This combination may offer a more comprehensive approach to mental well-being.

Boswellia: Boswellia, like Cat’s Claw, is used to manage inflammation and pain. Combining these two herbs can provide a more robust approach to addressing conditions like osteoarthritis.

Siberian Ginseng: If you’re looking to boost your energy and combat fatigue, pairing Cat’s Claw with Siberian ginseng can provide a natural energy boost and improve vitality.

Peppermint: For digestive health, combining Cat’s Claw with Peppermint can help soothe gastrointestinal discomfort and promote a healthy digestive system.

Ashwagandha: Cat’s Claw can complement Ashwagandha for stress reduction and mental well-being. Together, they may provide a holistic approach to managing stress and anxiety.

Cat’s Claw: Potential side effects

While Cat’s Claw offers numerous potential health benefits, it’s important to be aware of the possible side effects that can accompany its use. As with any herbal supplement, it’s essential to make informed decisions about incorporating it into your health regimen.

Allergic Reactions

Some individuals may experience allergic reactions to Cat’s Claw. Symptoms can include skin rash, itching, and swelling. If you’re allergic to plants in the Rubiaceae family, such as coffee or gardenia, you may be at a higher risk of an allergic response to Cat’s Claw.

Gastrointestinal Distress

In some cases, Cat’s Claw may cause stomach discomfort, including nausea, diarrhea, or abdominal pain. This is more likely to occur when taken in excessive amounts. To minimize these effects, it’s essential to follow recommended dosages.

Blood Pressure Regulation

Cat’s Claw has the potential to lower blood pressure. If you already have low blood pressure, combining Cat’s Claw with other medications or supplements that affect blood pressure may lead to hypotension, which can cause dizziness and fainting.

Blood Clotting

Cat’s Claw may have blood-thinning effects. While this can be beneficial for some individuals, it can be problematic for those taking blood-thinning medications like Warfarin. Combining Cat’s Claw with these medications can increase the risk of bleeding.

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, it’s advisable to exercise caution when using Cat’s Claw. Limited research is available on its safety during these periods, so it’s best to consult with a healthcare professional before use.

Drug Interactions

Cat’s Claw can interact with various medications, including those for hypertension, antiplatelet drugs, and anticoagulants. It’s crucial to inform your healthcare provider about any herbal supplements you are taking to avoid potential interactions.

Find the Best Cat’s Claw Products

Thousands of customer reviews are available to help you make the right choice. Embrace the power of nature!

Precautions and contraindications

Before incorporating Cat’s Claw into your health routine, it’s essential to consider precautions and contraindications to ensure your well-being and safety. While Cat’s Claw offers various potential benefits, it may not be suitable for everyone.


As mentioned earlier, some individuals may be allergic to Cat’s Claw, particularly if they have allergies to plants in the Rubiaceae family. If you have a history of plant allergies, it’s advisable to perform an allergy test or consult with a healthcare professional before using Cat’s Claw.


Using the recommended dosage is crucial to avoid adverse effects. Excessive consumption of Cat’s Claw can lead to stomach discomfort, such as nausea and diarrhea. Always adhere to the guidelines provided on the product label or consult with a healthcare provider for proper dosing.

Blood Pressure

If you have low blood pressure, it’s important to be cautious when using Cat’s Claw, as it may further reduce your blood pressure. Monitor your blood pressure regularly and consult with your healthcare provider to ensure your well-being.

Pregnancy and Breastfeeding

Limited research is available on the safety of Cat’s Claw during pregnancy and breastfeeding. Due to the potential risks, it’s advisable to avoid its use during these periods unless under the guidance of a qualified healthcare professional.

Autoimmune Disorders

Cat’s Claw’s immune-boosting properties may not be suitable for individuals with autoimmune disorders. Stimulating the immune system can exacerbate these conditions. If you have an autoimmune disorder, consult with a healthcare provider before using Cat’s Claw.

Blood Clotting Disorders

Cat’s Claw’s blood-thinning effects can be problematic for individuals with blood clotting disorders or those taking anticoagulant medications. The risk of bleeding may increase, making it essential to consult with a healthcare provider before use.

Consult with a Healthcare Professional

It’s crucial to consult with a healthcare professional before using Cat’s Claw, especially if you have underlying health conditions or are taking medications. They can guide whether Cat’s Claw is suitable for you and help you navigate any potential interactions or contraindications.

Cat’s Claw: Drug interactions

Understanding potential drug interactions is crucial when considering the use of Cat’s Claw as a supplement. While Cat’s Claw offers various health benefits, it can interact with medications, affecting their efficacy and safety. Here are some important drug interactions to be aware of:

1. Anticoagulants and Antiplatelet Medications

Cat’s Claw has blood-thinning properties, which can lead to increased bleeding risk. If you’re taking anticoagulants like Warfarin or antiplatelet drugs such as Aspirin, combining them with Cat’s Claw may further enhance these effects. This can lead to excessive bleeding and bruising.

2. Hypertension Medications

Cat’s Claw may lower blood pressure. If you’re on medications to manage high blood pressure, combining them with Cat’s Claw could cause a significant drop in blood pressure, leading to dizziness or fainting. It’s crucial to monitor your blood pressure regularly and consult with your healthcare provider if you choose to use Cat’s Claw.

3. Immunosuppressants

The immune-boosting properties of Cat’s Claw can interact with immunosuppressive medications. If you’re on these drugs to suppress your immune response, using Cat’s Claw may counteract their effects, potentially worsening autoimmune conditions.

4. Antihypertensive Medications

If you’re taking medications to lower blood pressure, combining them with Cat’s Claw can lead to an excessive reduction in blood pressure. This can result in lightheadedness and dizziness.

5. Anti-diabetic Medications

Cat’s Claw may affect blood sugar levels. If you’re using anti-diabetic medications, the combination can lead to unexpected changes in blood sugar, potentially causing hypoglycemia or hyperglycemia. Regular monitoring and consultation with your healthcare provider are essential.

6. Anti-inflammatory Medications

Cat’s Claw’s anti-inflammatory properties may interact with anti-inflammatory medications. Combining them can lead to enhanced anti-inflammatory effects, which might be beneficial or potentially excessive, depending on your specific health condition.

7. Herbal Supplements

If you’re taking other herbal supplements in addition to Cat’s Claw, it’s important to be aware of potential interactions. Some combinations may enhance the benefits of both supplements, while others can lead to adverse effects.

Cat’s Claw dosage and forms

Cat’s Claw is available in various forms, and the appropriate dosage can vary based on individual health needs and the form in which it is taken. Understanding the different forms and dosages is essential for safe and effective use.

Forms of Cat’s Claw

Cat’s Claw is available in the following common forms:

  • Capsules and Tablets: These are convenient and provide precise dosing. Typical doses range from 250 mg to 1000 mg per day, but dosages may vary depending on the brand and product.
  • Tinctures: Tinctures are liquid extracts of Cat’s Claw. They are typically taken in dropper form and can be added to water or juice. The recommended dosage usually ranges from 20 to 40 drops, 2-3 times per day.
  • Teas: Cat’s Claw can be brewed into tea. The dosage depends on the concentration of the tea, but a common recommendation is to drink 2-3 cups per day.
  • Powders: Cat’s Claw powder can be mixed into smoothies, yogurt, or other beverages. A typical dose ranges from 1 to 3 grams per day.
  • Topical Creams: Cat’s Claw creams are used for skin conditions. Apply a thin layer to the affected area as needed.

Dosage Guidelines

The appropriate dosage of Cat’s Claw can vary based on several factors, including individual health concerns and the form of the supplement. Here are some general guidelines:

  • For Immune Support: A typical dosage for immune support is 250-500 mg per day in capsule form.
  • For Anti-Inflammatory Effects: To manage inflammation and arthritis, a range of 1000-1500 mg per day may be recommended.
  • For Digestive Health: Dosages for digestive health can vary, but typically range from 250-500 mg daily.
  • For General Health and Well-being: If you are using Cat’s Claw as a general health supplement, a dosage of 500 mg daily may be suitable.

It’s important to note that individual responses to Cat’s Claw can vary, and it’s advisable to start with a lower dosage and gradually increase as needed. Additionally, consult with a healthcare professional for personalized guidance based on your specific health concerns.

Find the Best Cat’s Claw Products

Thousands of customer reviews are available to help you make the right choice. Embrace the power of nature!

The bottom line

As we conclude our exploration of Cat’s Claw, it’s essential to recap the key points and provide a clear understanding of its benefits, uses, potential side effects, and considerations.

Key Takeaways

  • Cat’s Claw (Uncaria tomentosa) is a vine native to the Amazon rainforest, known for its potential health benefits.
  • Indigenous Amazonian tribes have used Cat’s Claw for centuries to address various health issues, and it holds spiritual significance in their culture.
  • Cat’s Claw has potential medicinal benefits, including immune system support, anti-inflammatory effects, and antioxidant properties.
  • When used in combination with other herbs, Cat’s Claw can provide synergistic health benefits.
  • Potential side effects of Cat’s Claw may include allergic reactions, gastrointestinal distress, and blood pressure regulation.
  • Precautions and contraindications involve allergies, dosage, blood pressure, pregnancy, and underlying health conditions.
  • Cat’s Claw can interact with medications, including anticoagulants, immunosuppressants, and anti-diabetic drugs, among others.
  • The appropriate dosage of Cat’s Claw varies based on the form of the supplement and individual health needs.


Cat’s Claw is a unique herbal supplement with a rich history in traditional medicine and potential health benefits in the modern world. If you’re considering incorporating Cat’s Claw into your health regimen, it’s crucial to do so with caution and under the guidance of a healthcare professional.

Before using Cat’s Claw, consult with your healthcare provider to ensure that it is safe and appropriate for your specific health concerns and any medications you may be taking. By taking these precautions, you can harness the potential benefits of Cat’s Claw while safeguarding your well-being.

Remember that natural remedies should complement, not replace, medical treatment when necessary. With the right knowledge and guidance, Cat’s Claw may become a valuable addition to your journey toward better health and well-being.

We hope this information empowers you to make informed decisions about your health and wellness.

Frequently Asked Questions

Unlocking the Mysteries of Cat’s Claw: Your Comprehensive Guide

Article Sources

At AncientHerbsWisdom, our content relies on reputable sources, including peer-reviewed studies, to substantiate the information presented in our articles. Our primary objective is to ensure that our content is thoroughly fact-checked, maintaining a commitment to accuracy, reliability, and trustworthiness.

  1. Hardin S.R. “Cat’s claw: an Amazonian vine decreases inflammation in osteoarthritis.” Complementary Therapies in Clinical Practice. 2007 Feb;13(1):25-8. http://www.ncbi.nlm.nih.gov/pubmed/17210508 
  2. Piscoya J, Rodriguez Z, Bustamante SA, et al. Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 2001;50:442-8.
  3. Akesson C., Lindgren H., Pero R.W., Leanderson T., Ivars F. “Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100.” International Immunopharmacology. 2005 Jan;5(1):219-29. http://www.ncbi.nlm.nih.gov/pubmed/15589483 
  4. Riva L, Coradini D, Di Fronzo G, et al. The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res. Jul-Aug 2001;21(4A):2457-2461. 
  5. Jürgensen S., Dalbó S., Angers P., Santos A.R., Ribeiro-do-Valle R.M. “Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.” Pharmacology, Biochemistry and Behavior. 2005 Jul;81(3):466-77. http://www.ncbi.nlm.nih.gov/pubmed/15907989 
  6. Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol 1993;38:63-77.
  7. Sheng Y., Li L., Holmgren K., Pero R.W. “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study.”Phytomedicine. 2001 Jul;8(4):275-82. http://www.ncbi.nlm.nih.gov/pubmed/11515717 
  8. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med. Jul 1 2000;29(1):71-78. 
  9. Keplinger H. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same. US Patent no. 5,302,611, April 12, 1994.
  10. Weiss J. Herb⁻Drug Interaction Potential of Anti-Borreliae Effective Extracts from Uncaria tomentosa (Samento) and Otoba parvifolia (Banderol) Assessed In Vitro. Molecules. 2018 Dec 31;24(1). pii: E137. 
  11. Shi Z., Lu Z., Zhao Y., Wang Y., Zhao-Wilson X., Guan P., Duan X., Chang Y.Z., Zhao B. “Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model.” Neurochemistry International. 2013 Jun;62(7):940-7. http://www.ncbi.nlm.nih.gov/pubmed/23500604 
  12. Aquino R, De Feo V, De Simone F, et al. Plant metabolites, new compounds and anti-inflammatory activity of Uncaria tomentosa. J Nat Prod 1991;54:453-9.
  13. Rizzi R., Re F., Bianchi A., De Feo V., de Simone F., Bianchi L., Stivala L.A. “Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.” Journal of Ethnopharmacology. 1993 Jan;38(1):63-77. http://www.ncbi.nlm.nih.gov/pubmed/8479203 
  14. Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol 1993;38:63-77.
  15. Aguilar J.L., Rojas P., Marcelo A., Plaza A., Bauer R., Reininger E., Klaas C.A., Merfort I. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” Journal of Ethnopharmacology. 2002 Jul;81(2):271-6. http://www.ncbi.nlm.nih.gov/pubmed/12065162 
  16. Cosentino C, Torres L. Reversible worsening of Parkinson’s disease motor symptoms after oral intake of Uncaria tomentosa (cat’s claw). Clin Neuropharmacol 2008;31:293-4.
  17. Mohamed A.F., Matsumoto K., Tabata K., Takayama H., Kitajima M., Watanabe H. “Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.” Journal of Pharmacy and Pharmacology. 2000 Dec;52(12):1553-61. http://www.ncbi.nlm.nih.gov/pubmed/11197086 
  18. Sandoval M, Okuhama NN, Zhang XJ, et al. Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. May 2002;9(4):325-337. 
  19. Bacher N., Tiefenthaler M., Sturm S., Stuppner H., Ausserlechner M.J., Kofler R., Konwalinka G. “Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.” British Journal of Haematology. 2006 Mar;132(5):615-22. http://www.ncbi.nlm.nih.gov/pubmed/16445836 
  20. Garcia Prado E, Garcia Gimenez MD, De la Puerta Vazquez R, et al. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine. Apr 2007;14(4):280-284.
  21. Spelman K., Burns J., Nichols D., Winters N., Ottersberg S., Tenborg M. “Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators.” Alternative Medicine Revue. 2006 Jun;11(2):128-50. http://www.ncbi.nlm.nih.gov/pubmed/16813462 
  22. Dreifuss AA, Bastos-Pereira AL, Fabossi IA, et al. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity. PLoS One. 2013;8(2):e54618. 
  23. Barnes C.A. “Long-term potentiation and the ageing brain.”Philosophical Transactions of the Royal Society of London Series B Biological Sciences. 2003 Apr 29;358(1432):765-72. http://www.ncbi.nlm.nih.gov/pubmed/12740124/ 
  24. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. Feb 2000;69(2):115-126. 
  25. Kang T.H., Murakami Y., Takayama H., Kitajima M., Aimi N., Watanabe H., Matsumoto K. “Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action.” Life Sciences. 2004 Dec 3;76(3):331-43. https://www.ncbi.nlm.nih.gov/pubmed/15531384 
  26. Mur E, Hartig F, Eibl G, Schirmer M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29:678-81.
  27. Huang H., Zhong R., Xia Z., Song J., Feng L. “ Neuroprotective effects of rhynchophylline against ischemic brain injury via regulation of the Akt/mTOR and TLRs signaling pathways.” Molecules. 2014 Jul 30;19(8):11196-210. http://www.ncbi.nlm.nih.gov/pubmed/25079660 
  28. Caon T, Kaiser S, Feltrin C, et al. Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food Chem Toxicol. Apr 2014;66:30-35. 
  29. Riva L., Coradini D., Di Fronzo G., De Feo V., De Tommasi N., De Simone F., Pizza C. “The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line.”Anticancer Research. 2001 Jul-Aug;21(4A):2457-61. http://www.ncbi.nlm.nih.gov/pubmed/11724307 
  30. Farias I, do Carmo Araujo M, Zimmermann ES, et al. Uncaria tomentosa stimulates the Journal of Ethnopharmacology. 2000 Feb;69(2):115-26. http://www.ncbi.nlm.nih.gov/pubmed/10687868