All You Need to Know About Horse Chestnut: 50 Common Queries Answered

Horse Chestnut, a tree with a rich history in traditional medicine and botanical lore, has long been the subject of curiosity and interest. In this comprehensive article, we delve into 50 of the most common questions about this remarkable natural resource, offering insights and knowledge to help you better understand its uses, benefits, and potential applications. Whether you’re seeking information on its health benefits, cultivation, or historical significance, this guide aims to provide you with the answers you’re looking for.

Horse Chestnut: 50 Questions & Answers

What is Horse Chestnut?

Horse Chestnut is a deciduous tree native to the Balkans and is widely cultivated across Europe and North America for its ornamental and medicinal properties. It is widely recognized for its distinctive palmate leaves and showy white or pink flowers.

What is the scientific name of Horse Chestnut?

The scientific name of Horse Chestnut is Aesculus hippocastanum.

Does Horse Chestnut have other common names?

Aside from its botanical name, Horse Chestnut also goes by several common names, including Conker Tree, Buckeye, and Spanish Chestnut, among others.

What is Horse Chestnut’s traditional and modern medicinal use?

Traditionally, Horse Chestnut has been used in herbal medicine to address various health concerns. Its seeds, bark, and leaves have been employed for their potential medicinal properties. Historically, it was used to treat hemorrhoids, varicose veins, and edema due to its believed ability to strengthen blood vessels and reduce swelling. Modern research has focused on its compound called aescin, which may have anti-inflammatory and venotonic effects, making it a potential remedy for circulatory problems and chronic venous insufficiency.

What nutrients (vitamins, minerals, antioxidants, etc.) does Horse Chestnut contain?

Horse Chestnut is a source of several nutrients and bioactive compounds. Aescin, the aforementioned compound, is a prominent component known for its anti-inflammatory properties. It also contains saponins, flavonoids, and tannins, which contribute to its potential medicinal benefits. While not a significant source of vitamins and minerals, it does provide small amounts of vitamin K and trace minerals such as manganese.

It’s essential to note that while Horse Chestnut has potential health benefits, it should be used cautiously and under the guidance of a healthcare professional due to the risk of side effects and interactions with certain medications. Always consult with a healthcare provider before incorporating it into your health regimen.

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Are there any potential side effects associated with Horse Chestnut?

While Horse Chestnut is generally considered safe when used appropriately, some individuals may experience side effects. The most common side effects include gastrointestinal issues such as stomach upset, nausea, and diarrhea. Skin irritation can also occur if the seed or its extract comes into contact with the skin. In rare cases, allergic reactions like itching, rash, or swelling may happen. It’s advisable to consult with a healthcare professional before using Horse Chestnut, especially if you have a history of allergies or are taking medications.

The recommended dosage for Horse Chestnut can vary depending on the form of the product you’re using, whether it’s a topical cream, capsules, or a tincture. However, a common oral dose for adults is typically 250-500 milligrams of standardized extract (containing 16-20% aescin) taken two to three times daily. It’s essential to follow the instructions on the specific product you’re using, as dosages can vary among brands. Consulting a healthcare provider is wise to determine the appropriate dose for your individual needs.

Is Horse Chestnut safe for pregnant or breastfeeding women?

Horse Chestnut is generally not recommended for pregnant or breastfeeding women. While it’s considered safe for most adults when used as directed, there is limited research on its safety during pregnancy and lactation. The potential side effects and lack of comprehensive studies make it advisable to avoid using Horse Chestnut during these periods. Pregnant or breastfeeding women should always consult their healthcare provider before considering any herbal supplements.

Can children safely consume Horse Chestnut?

Horse Chestnut is not recommended for children without the guidance of a healthcare professional. The safety and appropriate dosages for children have not been well-established through research. It’s crucial to exercise caution and consult with a healthcare provider before giving Horse Chestnut to children.

How should Horse Chestnut be prepared or consumed (e.g., tea, tincture, capsules, tablets)?

Horse Chestnut is commonly available in various forms, including capsules, tablets, tinctures, and creams. The choice of how to consume it depends on your specific needs and preferences. Capsules or tablets are convenient for oral consumption and provide standardized doses of the active compound, aescin. Tinctures are liquid extracts and can be diluted in water for consumption. Creams or ointments are applied topically and are suitable for skin-related issues. There is no commonly recommended form for everyone, so it’s essential to choose the one that suits your intended use and consult with a healthcare provider for specific guidance on dosage and application.

Are there any contraindications or health conditions that may be worsened by Horse Chestnut?

Yes, there are contraindications associated with Horse Chestnut. Individuals with allergies to the Aesculus species, pregnant or nursing women, and people with bleeding disorders or liver disease should avoid its use. Additionally, those taking blood thinners or antiplatelet drugs should exercise caution and consult a healthcare professional before using Horse Chestnut.

Where is Horse Chestnut usually sourced or cultivated?

Horse Chestnut, scientifically known as Aesculus hippocastanum, is commonly sourced and cultivated in regions of Europe and Asia. It thrives in temperate climates and is often found in parks, gardens, and as ornamental trees in these regions.

In the United States, Horse Chestnut supplements are generally available and legal to possess and use as dietary supplements. However, it’s important to purchase them from reputable sources to ensure their quality and safety.

Are there any known allergens in Horse Chestnut?

Horse Chestnut itself does not contain common allergens like nuts or gluten. However, as with any natural product, there is a possibility of cross-contamination during processing or manufacturing. Individuals with known allergies should check the product’s label and consult with their healthcare provider if they have concerns.

May Horse Chestnut supplements contain contaminants like pesticides or heavy metals?

Like many botanical supplements, Horse Chestnut supplements may carry the risk of containing contaminants such as pesticides or heavy metals if not sourced and manufactured properly. To mitigate this risk, consumers should choose products from reputable companies that adhere to quality control standards and third-party testing. This ensures that the supplements meet safety and purity criteria. Regularly checking for product certifications can provide further assurance of their quality.

Are there any known long-term effects of using Horse Chestnut?

Horse Chestnut supplements are generally safe for short-term use, but there is limited information available regarding their long-term effects. It’s essential to consult with a healthcare professional before considering extended usage. Some individuals may experience side effects such as digestive discomfort, itching, or headache, but these are usually mild and temporary.

Do Horse Chestnut supplements have a specific shelf life or expiration date?

Horse Chestnut supplements, like most herbal products, have a shelf life. The expiration date is typically indicated on the product packaging. It’s crucial to adhere to this date to ensure the potency and safety of the supplement. Using expired supplements may result in decreased effectiveness and potential health risks.

What is the best time of day to take Horse Chestnut?

The best time to take Horse Chestnut supplements may vary from person to person. However, many people find it convenient to take them in the morning with breakfast. This can help minimize the risk of potential digestive discomfort, as food can provide a protective buffer.

Should Horse Chestnut pills be taken with food or on an empty stomach?

Horse Chestnut supplements are generally better tolerated when taken with food. Consuming them with a meal can help reduce the likelihood of gastrointestinal side effects. If you have a sensitive stomach, taking them with a small meal or snack is a good practice.

Are there any dietary restrictions or guidelines while using Horse Chestnut?

While using Horse Chestnut supplements, there are no strict dietary restrictions. However, it’s advisable to maintain a balanced diet rich in fruits, vegetables, and whole grains. Avoid excessive alcohol consumption and consider moderating your caffeine intake, as these substances can affect circulation and potentially interact with Horse Chestnut’s effects. Always consult with a healthcare professional for personalized guidance based on your specific health needs.

The recommended duration of use for Horse Chestnut varies depending on the specific health issue you’re addressing. Typically, it’s used for 6-12 weeks for conditions like chronic venous insufficiency (CVI) and related symptoms. However, it’s crucial to consult with a healthcare professional to determine the appropriate duration for your individual needs.

Is it advisable to consult a healthcare professional before using Horse Chestnut?

Yes, it is advisable to consult a healthcare professional before using Horse Chestnut supplements, especially if you have any underlying health conditions or are taking medications. They can assess your specific situation and provide guidance on dosage and potential interactions.

Are there any special precautions for storing Horse Chestnut supplements?

When storing Horse Chestnut supplements, it’s essential to keep them in a cool, dry place, away from direct sunlight and moisture. Airtight containers or the original packaging are ideal for preserving their potency. Additionally, make sure to follow any specific storage instructions provided on the product label.

How does Horse Chestnut taste, and can it be mixed with other herbs or foods for palatability?

Horse Chestnut supplements typically do not have a strong taste, and some people describe them as slightly bitter. If you find the taste unpleasant, you can mix them with other herbs or foods to improve palatability. For example, you can blend them into smoothies, mix them with yogurt, or incorporate them into herbal tea blends.

What other supplements work well together with Horse Chestnut?

Horse Chestnut, known for its potential benefits related to circulatory health, can be combined with other supplements to support various aspects of well-being. Here are some supplements that can complement Horse Chestnut effectively:

  • Butcher’s Broom: Butcher’s Broom is often paired with Horse Chestnut to enhance circulatory health. This combination may help reduce the appearance of varicose veins and improve blood flow in the legs.
  • Ginkgo Biloba: Ginkgo Biloba supports overall blood circulation and cognitive function. When taken with Horse Chestnut, this combination can promote comprehensive vascular health.
  • Hawthorn: Combining Hawthorn with Horse Chestnut can aid in maintaining healthy blood pressure and supporting heart health.
  • Bilberry: Bilberry is known for its potential benefits on vision and eye health. When used alongside Horse Chestnut, it can promote better overall circulation.
  • Turmeric (Curcumin): Turmeric‘s anti-inflammatory properties may complement Horse Chestnut’s circulatory benefits. Together, they can provide support for overall joint health and inflammation reduction.
  • Vitamin C: Vitamin C is essential for collagen formation and maintaining the health of blood vessels. Taking it with Horse Chestnut can help support the structural integrity of blood vessels.
  • Diosmin: Diosmin is a flavonoid that, when combined with Horse Chestnut, can help reduce symptoms associated with chronic venous insufficiency, such as swelling and discomfort in the legs.
  • Magnesium: Magnesium is crucial for muscle and nerve function and can complement Horse Chestnut in promoting muscle relaxation and overall vascular health.

Is there any scientific research or clinical evidence supporting Horse Chestnut’s effectiveness?

Yes, scientific research and clinical evidence support the effectiveness of Horse Chestnut (Aesculus hippocastanum) for certain health conditions. It has been studied extensively for its potential benefits in managing chronic venous insufficiency (CVI) and varicose veins. Clinical trials have shown that standardized horse chestnut seed extract can reduce leg pain, swelling, and itching associated with these conditions. However, it’s essential to consult with a healthcare professional before using it as a treatment.

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Are there any age restrictions for using Horse Chestnut (e.g., suitable for the elderly)?

There are generally no specific age restrictions for using Horse Chestnut. However, it is crucial to consider individual factors and consult a healthcare provider, especially for children and the elderly, to determine the appropriate dosage and safety precautions. Horse Chestnut supplements may not be suitable for everyone, so personalized guidance is essential.

Does Horse Chestnut require a specific preparation method, such as decoction or infusion?

Horse Chestnut can be prepared in various ways, depending on the intended use. The most common form is a standardized extract, available in capsules or tablets. This form ensures a consistent dosage of the active compounds. It is typically taken orally with water. While traditional preparations like decoctions or infusions from the bark have been used historically, they are less common today due to the availability of standardized supplements.

Can Horse Chestnut be used topically (externally) in addition to internal consumption?

Yes, Horse Chestnut can be used topically, in the form of creams or gels, for external application. These topical products are often used to soothe symptoms associated with varicose veins, such as pain, swelling, and itching. When applying topically, follow the product’s instructions carefully and avoid open wounds or broken skin. Internal consumption and topical application can complement each other for enhanced benefits.

Are there any known symptoms of overdose or excessive use of Horse Chestnut?

Excessive use or overdose of Horse Chestnut can lead to adverse effects, such as nausea, vomiting, diarrhea, and dizziness. In severe cases, it may cause liver toxicity. It’s crucial to adhere to the recommended dosage on product labels or as advised by a healthcare professional. If you experience any adverse reactions or suspect an overdose, seek immediate medical attention. Horse Chestnut should not be used by individuals with liver disease or those taking anticoagulant medications without medical supervision. Always consult a healthcare provider before using it, especially if you have underlying health conditions or are on other medications.

What is Horse Chestnut’s mode of action within the body?

Horse Chestnut’s mode of action within the body primarily revolves around its active compound called aescin. Aescin has anti-inflammatory properties that can help reduce swelling and improve blood circulation. It works by strengthening blood vessel walls and reducing the leakage of fluid into surrounding tissues. This action is particularly beneficial for conditions like chronic venous insufficiency and varicose veins, where blood pools in the legs due to weakened veins.

Are there any known synergistic effects when Horse Chestnut is combined with specific nutrients?

When combined with specific nutrients like vitamin C and bioflavonoids, Horse Chestnut may exhibit synergistic effects. Vitamin C can enhance the absorption of aescin, while bioflavonoids support the overall health of blood vessels. This combination can potentially improve the effectiveness of Horse Chestnut in managing venous issues.

Does Horse Chestnut have a distinct aroma or essential oil that may have therapeutic benefits?

Horse Chestnut does not have a distinct aroma or essential oil commonly associated with aromatherapy. Its therapeutic benefits primarily come from internal use as a supplement or topical applications in the form of creams or gels for skin issues and circulatory support.

Are there any cultural or historical uses of Horse Chestnut that should be considered?

Historically, Horse Chestnut has found use in traditional medicine across Europe and Asia. In European herbal medicine, it has been employed for centuries to alleviate symptoms related to venous insufficiency, such as leg swelling and pain. Additionally, Native American tribes utilized parts of the Horse Chestnut tree for various medicinal purposes, including as a treatment for conditions like hemorrhoids.

Does Horse Chestnut have any spiritual or ceremonial significance in certain traditions?

While Horse Chestnut does not hold significant spiritual or ceremonial significance in mainstream traditions, it’s important to acknowledge that various cultures may have their interpretations or symbolic uses of trees. However, it is not widely recognized as having a distinct spiritual or ceremonial role in most traditions.

Are there any variations in Horse Chestnut’s potency based on its geographic origin?

Yes, there can be variations in the potency of Horse Chestnut based on its geographic origin. The active compounds in Horse Chestnut, primarily aescin, can vary in concentration depending on the climate, soil conditions, and other environmental factors where the plant is grown. Generally, European Horse Chestnut (Aesculus hippocastanum) is considered to have higher aescin content compared to other species.

Does Horse Chestnut have a known effect on specific organs or body systems?

Horse Chestnut is known to have effects primarily on the circulatory system. It has been traditionally used to alleviate symptoms of chronic venous insufficiency, such as swelling and pain in the legs. Its aescin content helps strengthen blood vessels, reduce inflammation, and improve blood flow in the veins.

Are there any known interactions of Horse Chestnut with commonly prescribed medications?

Yes, there are potential interactions between Horse Chestnut and certain medications. It may enhance the effects of anticoagulant medications like warfarin, increasing the risk of bleeding. It can also interact with antiplatelet drugs like aspirin or clopidogrel. It’s crucial to consult with a healthcare professional before using Horse Chestnut alongside prescribed medications to avoid adverse interactions.

What are the potential benefits and risks of long-term or chronic use of Horse Chestnut?

When used appropriately and under the guidance of a healthcare provider, short-term use of Horse Chestnut for specific conditions is generally considered safe. However, there are potential risks associated with long-term or chronic use. Prolonged use may lead to side effects like stomach upset, itching, or allergic reactions. It’s important to use it cautiously and monitor for any adverse effects, especially when used continuously for extended periods.

Is it advisable to cycle on and off Horse Chestnut to prevent tolerance or dependence?

There is no strict requirement to cycle on and off Horse Chestnut like some other supplements. However, it’s advisable to follow recommended dosages and not exceed them, as prolonged use may lead to tolerance or dependence on its effects. If you find that it’s less effective over time, consult with a healthcare professional for alternative treatments or approaches to your condition. Always prioritize open communication with your healthcare provider when considering any long-term use of supplements.

Are there any precautions regarding driving or operating machinery while using Horse Chestnut?

When using Horse Chestnut, it’s essential to exercise caution when driving or operating machinery. Some individuals may experience dizziness or drowsiness as a potential side effect. If you’re affected by these symptoms, it’s advisable to avoid activities that require full concentration until you’re certain about your tolerance to the supplement.

There are no specific dietary restrictions associated with the use of Horse Chestnut. However, maintaining a well-balanced diet can complement its effects. A diet rich in antioxidants and anti-inflammatory foods may enhance the overall benefits of Horse Chestnut in promoting vascular health. Regular exercise and smoking cessation, if applicable, can also contribute positively to its effects.

Does Horse Chestnut have any specific recommendations for addressing common side effects?

Common side effects of Horse Chestnut may include mild gastrointestinal discomfort, itching, or skin rash. If you encounter any of these side effects, it’s recommended to discontinue use and consult with a healthcare professional. They can offer alternative solutions or adjust the dosage to minimize adverse reactions.

Are there any known variations or subspecies of Horse Chestnut with different properties?

Aesculus hippocastanum, commonly known as Horse Chestnut, is a well-studied species with relatively consistent properties across its range. While there might be minor variations in the chemical composition of different cultivars, they generally share similar medicinal characteristics. It’s crucial to ensure you’re using Aesculus hippocastanum from reputable sources to guarantee its efficacy and safety.

Does Horse Chestnut have any documented cases of misuse or abuse?

Horse Chestnut, when used responsibly and as directed, has a low potential for misuse or abuse. It’s primarily used for its therapeutic benefits related to venous and circulatory issues. However, like any herbal remedy, excessive or improper use can lead to adverse effects. To prevent misuse, always follow recommended dosages and seek guidance from a healthcare professional when in doubt about its application or safety.

Is Horse Chestnut regulated or approved for medicinal use in the United States?

Horse Chestnut is not regulated or approved for medicinal use in the United States by the Food and Drug Administration (FDA). However, it is available as a dietary supplement and is commonly used in traditional herbal medicine.

Are there any known interactions of Horse Chestnut when combined with other medicinal herbs?

Yes, there are known interactions of Horse Chestnut when combined with other medicinal herbs. It can interact with anticoagulant medications, antiplatelet drugs, and other herbs with similar effects, potentially increasing the risk of bleeding. It’s crucial to consult with a healthcare professional before combining it with other herbs or medications.

How does Horse Chestnut’s preparation or dosage change for acute versus chronic conditions?

The preparation and dosage of Horse Chestnut can vary depending on whether it’s being used for acute or chronic conditions. For acute conditions like a sprained ankle or bruise, a topical cream or gel containing Horse Chestnut extract can be applied to the affected area. For chronic conditions like chronic venous insufficiency, standardized oral supplements are often recommended. The dosage should be determined by a healthcare provider, as it can vary based on the specific product and individual needs.

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Are there any known withdrawal symptoms when discontinuing the use of Horse Chestnut?

There are no known withdrawal symptoms associated with discontinuing the use of Horse Chestnut. However, it’s essential to follow the recommended dosage and usage guidelines provided by the product manufacturer or healthcare professional to avoid any potential side effects.

What are the best supplement brands of Horse Chestnut?

The best supplement brands for Horse Chestnut can vary depending on factors like product quality, dosage, and personal preferences. Some well-regarded brands known for their herbal supplements include Nature’s Way, NOW Foods, and Swanson. However, it’s advisable to research and consult with a healthcare professional to find the right brand and product that suits your specific needs and health goals.

Article References & Sources

At AncientHerbsWisdom, our content relies on reputable sources, including peer-reviewed studies, to substantiate the information presented in our articles. Our primary objective is to ensure our content is thoroughly fact-checked, maintaining a commitment to accuracy, reliability, and trustworthiness.

  1. Horse chestnut. (2018).
    https://www.ncbi.nlm.nih.gov/books/NBK548217
  2. MedlinePlus. Maritime Pine.
  3. National Park Service. https://www.nps.gov/articles/000/cny-treephenology-horsechestnut.htm 
  4. Horse chestnut (2020).
    https://www.nccih.nih.gov/health/horse-chestnut
  5. Azhdari M, Zilaee M, Karandish M, et al. Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. Phytother Res. 2020;34(10):2577-2585. doi:10.1002/ptr.6705
  6. Aesculus (N) – horse chestnut tincture. (2021).
    https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b9fb953e-f40d-4f23-af1d-4c22b9121219
  7. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med. 2021;8(4):333-335. doi:10.15441/ceem.20.004
  8. Aesculus hippocastanum – horse chestnut pellet. (2019).
    https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8410dc8b-382c-8f38-e053-2a91aa0a850d
  9. Sharipov, A. M., et al. (2021). Hypoglycemic and anti-inflammatory effects of triterpene glycoside fractions from Aesculus hippocastanum seeds.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270310
  10. Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Des Devel Ther. 2019;13:3425-3437. doi:10.2147/DDDT.S207720
  11. Dudeck-Makuch, M., et al. (2015). Horse chestnut – efficacy and safety in chronic venous insufficiency: An overview.
    https://www.sciencedirect.com/science/article/pii/S0102695X15001003
  12. Fang Y, Zhao L, Yan F, Xia X, Xu D, Cui X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. doi:10.1016/j.phymed.2009.07.014
  13. European Union herbal monograph on Aesculus hippocastanum L., semen. (2019).
    https://www.ema.europa.eu/en/documents/herbal-monograph/draft-european-union-herbal-monograph-aesculus-hippocastanum-l-semen-revision-1_en.pdf
  14. Sankhwar SN, Kumar P, Bagchi M, Rungta M, Bagchi D. Safety and efficacy of Furosap®, a patented Trigonella foenum-graecum seed extract, in boosting testosterone level, reproductive health and mood alleviation in male volunteers. J Am Nutr Assoc. 2023;42(1):27-35. doi:10.1080/07315724.2021.1978348
  15. Gallelli, L., et al. (2019). Escin: A review of its anti-edematous, anti-inflammatory, and venotonic properties.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776292
  16. Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866. doi:10.3390/nu9080866
  17. Horse chestnut. (n.d.).
    https://www.wildlifetrusts.org/wildlife-explorer/trees-and-shrubs/horse-chestnut
  18. Ge B, Zhang Z, Zuo Z. Updates on the clinical evidenced herb-warfarin interactions. Evid Based Complement Alternat Med. 2014;2014:957362. doi:10.1155/2014/957362
  19. Horse chestnut. (n.d.).
    https://www.woodlandtrust.org.uk/trees-woods-and-wildlife/british-trees/a-z-of-british-trees/horse-chestnut
  20. National Center for Complementary and Integrative Health. Horse chestnut.
  21. Idris, S., et al. (2020). Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine.
    https://www.degruyter.com/document/doi/10.1515/jbcpp-2019-0115/html?lang=en
  22. Idris S, Mishra A, Khushtar M. Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine. J Basic Clin Physiol Pharmacol. 2020;31(5):/j/jbcpp.2020.31.issue-5/jbcpp-2019-0115/jbcpp-2019-0115.xml. doi:10.1515/jbcpp-2019-0115
  23. Karatoprak, G. Ş. (2019). Horse chestnut.
    https://www.sciencedirect.com/science/article/pii/B9780128124918000424#!
  24. Yao DF, Mills JN. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian J Androl. 2016;18(3):410-418. doi:10.4103/1008-682X.175779
  25. Melegova, N., et al. (2022). Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma [Abstract].
    https://pubmed.ncbi.nlm.nih.gov/34962824
  26. Stuart, A. G. Horse chestnut. (n.d.).
    https://www.utep.edu/herbal-safety/herbal-facts/herbal%20facts%20sheet/horse-chestnut%20.html
  27. Patel, S. K., et al. (2021). Venous insufficiency (n.d.).
    https://www.ncbi.nlm.nih.gov/books/NBK430975
  28. Dudek-Makuch M, Studzinska-Sroka E. Horse chestnut – efficacy and safety in chronic venous insufficiency: an overview. Rev Bras. 2015;25(5):533-541. doi:10.1016/j.bjp.2015.05.009

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