Exploring Milk Thistle: 50 Questions to Enhance Your Understanding

Milk Thistle, renowned for its potential health benefits, has become a subject of curiosity among those interested in herbal remedies. As we embark on a journey to uncover the various aspects of this botanical wonder, we find ourselves facing a plethora of questions. In this article, we aim to shed light on 50 of the most common inquiries about Milk Thistle, ultimately enriching your comprehension of this herbal remedy.

Milk Thistle: 50 Questions & Answers

What is Milk Thistle?

Milk Thistle is an herbal plant renowned for its potential medicinal properties. It belongs to the Asteraceae family and is characterized by its striking purple flowers and spiky leaves. This herbaceous plant has a rich history of use in traditional medicine, primarily for its reputed liver-supporting qualities.

What is the scientific name of Milk Thistle?

The scientific name of Milk Thistle is Silybum marianum. This botanical name is derived from the genus Silybum, which encompasses various thistle-like plants, and the specific epithet marianum, referring to its association with the Virgin Mary in Christian folklore.

Does Milk Thistle have other common names?

Milk Thistle has several common names, reflecting its widespread recognition and usage. Aside from its scientific name, it is often referred to as St. Mary’s Thistle, Marian Thistle, and Holy Thistle. These alternative names stem from historical and cultural associations, with “St. Mary’s Thistle” alluding to its legendary use in treating liver ailments and “Holy Thistle” underscoring its reputation as a potent healer.

What is Milk Thistle’s traditional and modern medicinal use?

Milk Thistle has a rich history of medicinal use dating back to ancient times. Traditionally, it was primarily used to treat liver and gallbladder disorders. Its seeds contain a group of compounds called silymarin, which are believed to have hepatoprotective properties, helping to protect and support the liver. In modern herbal medicine, Milk Thistle is still widely used for liver health and is also explored for its potential benefits in managing conditions like fatty liver disease and alcohol-induced liver damage.

What nutrients (vitamins, minerals, antioxidants, etc.) does Milk Thistle contain?

Milk Thistle is a rich source of nutrients, including vitamins such as vitamin E and vitamin C, which act as antioxidants, helping to combat free radicals in the body. It also contains minerals like zinc, selenium, and potassium. However, its most well-known component is silymarin, which is a flavonoid complex with antioxidant and anti-inflammatory properties. Silymarin is considered the key bioactive compound responsible for many of Milk Thistle’s potential health benefits, especially in supporting liver function and detoxification processes.

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Are there any potential side effects associated with Milk Thistle?

While Milk Thistle is generally considered safe for most individuals, some mild and infrequent side effects have been reported. These may include gastrointestinal issues like upset stomach, diarrhea, or bloating. However, these side effects tend to be rare and mild. In very rare cases, individuals with allergies to plants in the Asteraceae family (such as ragweed, marigolds, or daisies) may experience allergic reactions when consuming Milk Thistle.

The recommended dosage of Milk Thistle can vary depending on the form you choose, such as capsules, tinctures, or teas. Typically, for standardized Milk Thistle extract capsules, a common dosage ranges from 200 to 400 milligrams taken one to three times daily. However, it’s essential to consult with a healthcare professional to determine the appropriate dosage for your specific needs and any underlying health conditions.

Is Milk Thistle safe for pregnant or breastfeeding women?

The safety of Milk Thistle during pregnancy and breastfeeding is still not definitively established. While there is limited evidence to suggest it might be safe, pregnant and breastfeeding women should consult with their healthcare provider before using Milk Thistle or any other herbal supplements to ensure there are no potential risks to the mother or the baby.

Can children safely consume Milk Thistle?

Milk Thistle is generally considered safe for children when used appropriately and under the guidance of a healthcare professional. However, it’s crucial to adjust the dosage based on the child’s age, weight, and specific health needs. Always consult with a pediatrician or healthcare provider before giving Milk Thistle or any herbal remedies to children.

How should Milk Thistle be prepared or consumed (e.g., tea, tincture, capsules, tablets)?

Milk Thistle can be consumed in various forms, including capsules, tablets, tinctures, and teas. Capsules and tablets are convenient for precise dosing and are typically taken with water. Tinctures involve using an alcohol-based extract, and a few drops can be added to water or juice. As for teas, you can brew them by steeping Milk Thistle seeds in hot water. The choice of preparation method depends on personal preference and the desired therapeutic effect. It’s essential to follow the recommended dosage instructions on the product label or as advised by a healthcare professional.

Are there any contraindications or health conditions that Milk Thistle may worsen?

Milk Thistle is generally considered safe for most people when used as directed. However, individuals with a known allergy to plants in the Asteraceae family, such as ragweed, marigolds, or daisies, may experience allergic reactions to Milk Thistle. It’s important to consult with a healthcare professional before starting any new supplement, especially if you have allergies or underlying health conditions.

Where is Milk Thistle usually sourced or cultivated?

Milk Thistle, scientifically known as Silybum marianum, is native to the Mediterranean region but is now widely cultivated around the world. In the United States, it’s primarily grown in states like California and Texas. The seeds of the Milk Thistle plant are used to extract the active compounds for various herbal preparations and supplements.

Yes, Milk Thistle is legal to possess and use in the United States. It is available as an over-the-counter dietary supplement and is not classified as a controlled substance. However, it’s essential to follow recommended dosages and consult with a healthcare provider, especially if you’re pregnant, nursing, or taking medications.

Are there any known allergens in Milk Thistle?

Milk Thistle supplements are generally safe for most people and do not contain common allergens like gluten or soy. However, as mentioned earlier, individuals with known allergies to plants in the Asteraceae family should exercise caution and consider alternatives. Always check the product label for any specific allergen warnings.

May Milk Thistle supplements contain contaminants like pesticides or heavy metals?

Milk Thistle supplements can contain contaminants like pesticides or heavy metals, depending on the sourcing and manufacturing processes. To ensure the purity and quality of the product, it’s advisable to choose reputable brands that conduct third-party testing and adhere to good manufacturing practices (GMP). These tests can confirm the absence of contaminants and provide a safer product for consumption.

Are there any known long-term effects of using Milk Thistle?

Milk Thistle is generally considered safe for short-term use, but there’s limited research on its long-term effects. Some studies have reported extended use without significant adverse effects. However, to ensure safety, it’s advisable to consult with a healthcare professional if you plan to use Milk Thistle supplements regularly over an extended period.

Do Milk Thistle supplements have a specific shelf life or expiration date?

Yes, Milk Thistle supplements, like most dietary products, have a shelf life. Typically, they come with an expiration date mentioned on the packaging. It’s important to adhere to this date to ensure the potency and effectiveness of the product. Using expired supplements may not provide the intended health benefits.

What is the best time of day to take Milk Thistle?

There isn’t a strict rule regarding the best time to take Milk Thistle. Some people prefer to take it in the morning with breakfast, while others choose to take it with other supplements or at a different time of day. It’s generally recommended to be consistent with your timing once you find a schedule that works for you.

Should Milk Thistle pills be taken with food or on an empty stomach?

Milk Thistle can be taken with or without food, depending on personal preference and tolerance. Some individuals may find it more comfortable to take with a meal to reduce the likelihood of gastrointestinal discomfort. Others may prefer an empty stomach for faster absorption. Experiment and see which method suits you best.

Are there any dietary restrictions or guidelines while using Milk Thistle?

Milk Thistle is generally safe when used as directed. However, if you have specific dietary restrictions or are taking other medications, it’s advisable to consult with a healthcare professional. There are no strict dietary guidelines associated with Milk Thistle, but it’s essential to maintain a balanced diet and stay hydrated while using it to support overall health and well-being.

The recommended duration of use for Milk Thistle can vary depending on your specific health needs. Generally, it is considered safe for short-term use (up to 6 months) to support liver health or address specific issues. However, if you plan to use it for an extended period, it’s crucial to consult a healthcare professional for guidance.

Is it advisable to consult a healthcare professional before using Milk Thistle?

Yes, it is advisable to consult a healthcare professional before using Milk Thistle, especially if you have underlying medical conditions, are pregnant or nursing, or are taking other medications. They can assess your health situation and provide personalized recommendations on dosage and potential interactions.

Are there any special precautions for storing Milk Thistle supplements?

When it comes to storing Milk Thistle supplements, it’s essential to keep them in a cool, dry place, away from direct sunlight and moisture. Seal the container tightly to prevent exposure to air, which can lead to degradation of the active compounds. Follow the specific storage instructions on the product label for optimal freshness.

How does Milk Thistle taste, and can it be mixed with other herbs or foods for palatability?

Milk Thistle typically has a mildly bitter taste. While it can be consumed on its own, many people prefer to mix it with other herbs or foods to improve palatability. Common methods include blending it into smoothies, adding it to herbal teas, or incorporating it into recipes with complementary flavors.

What other supplements work well together with Milk Thistle?

Milk Thistle is a versatile herb that can complement various other supplements to enhance overall health and well-being. Here are some supplements that work well when combined with Milk Thistle:

  • Turmeric (Curcumin): Combining Milk Thistle with Turmeric or its active compound, curcumin, can provide robust liver support. Both have potent antioxidant and anti-inflammatory properties, making them a powerful duo for overall health.
  • Dandelion Root: Dandelion root and Milk Thistle are both well-regarded for liver health. When used together, they can offer comprehensive detoxification and liver support.
  • N-Acetyl Cysteine (NAC): NAC is known for its ability to boost glutathione levels, an essential antioxidant for liver health. Combining NAC with Milk Thistle can provide strong support for liver detoxification.
  • Vitamin E: Vitamin E is an antioxidant that complements Milk Thistle’s liver-protective effects. This combination may help reduce oxidative stress in the liver.
  • Artichoke Leaf: Artichoke leaf extract can support liver and digestive health. When combined with Milk Thistle, it offers a synergistic approach to liver function and detoxification.
  • Selenium: Selenium is a mineral that plays a crucial role in liver health. It enhances the effects of Milk Thistle in protecting and supporting the liver.
  • Ginger: Ginger‘s anti-inflammatory properties can enhance the overall anti-inflammatory and liver-protective effects of Milk Thistle.
  • Choline: Choline is vital for fat metabolism in the liver. Combining it with Milk Thistle can provide comprehensive liver support, particularly for those concerned with fatty liver issues.

Is there any scientific research or clinical evidence supporting Milk Thistle’s effectiveness?

Yes, scientific research and clinical studies have provided some evidence supporting the effectiveness of Milk Thistle, particularly in promoting liver health. The active component, silymarin, is believed to have antioxidant and anti-inflammatory properties that may protect liver cells and support their regeneration. However, more research is needed to establish its efficacy in treating specific medical conditions definitively.

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Are there any age restrictions for using Milk Thistle (e.g., suitable for the elderly)?

Milk Thistle is generally considered safe for people of all ages, including the elderly. There are no specific age restrictions associated with its use. However, it’s essential to consult with a healthcare professional before starting any new supplement regimen, especially for individuals with underlying medical conditions or those taking medications.

Does Milk Thistle require a specific preparation method, such as decoction or infusion?

Milk Thistle can be consumed in various forms, including capsules, tablets, tinctures, and teas. There is no specific preparation method like decoction or infusion required for its internal use. It’s commonly available in standardized extract form, making it convenient for oral consumption.

Can Milk Thistle be used topically (externally) in addition to internal consumption?

While Milk Thistle is primarily used internally, there is some limited use of it topically. Some individuals use Milk Thistle-infused creams or oils for skin conditions like acne or eczema. However, it’s crucial to exercise caution and perform a patch test to ensure there are no adverse skin reactions. Consultation with a dermatologist is advisable before using it topically.

Are there any known symptoms of overdose or excessive use of Milk Thistle?

Milk Thistle is generally well-tolerated when taken at recommended dosages. However, excessive use or overdose may lead to mild gastrointestinal symptoms such as diarrhea or stomach cramps. In rare cases, an allergic reaction can occur. It’s essential to follow the recommended dosage guidelines on the product label or consult a healthcare professional to avoid any adverse effects associated with overuse.

What is Milk Thistle’s mode of action within the body?

Milk Thistle, scientifically known as Silybum marianum, primarily exerts its mode of action within the body through its active compound, silymarin. Silymarin is a potent antioxidant that can protect liver cells from damage caused by toxins, such as alcohol and certain medications. It does this by reducing oxidative stress and inflammation in the liver, promoting the regeneration of liver cells, and inhibiting the binding of harmful substances to liver cell membranes.

Are there any known synergistic effects when Milk Thistle is combined with specific nutrients?

When Milk Thistle is combined with specific nutrients like vitamin E or vitamin C, it can have synergistic effects on its antioxidant properties. These vitamins enhance the antioxidant capacity of silymarin, potentially increasing its effectiveness in protecting the liver and supporting overall health.

Does Milk Thistle have a distinct aroma or essential oil that may have therapeutic benefits?

Milk Thistle does have a distinct aroma, although it is not typically used for therapeutic purposes based on its scent. The aroma is mild and earthy, with a slightly nutty undertone. While its aroma is not a primary factor in its therapeutic benefits, some people find the scent pleasant and calming.

Are there any cultural or historical uses of Milk Thistle that should be considered?

Culturally and historically, Milk Thistle has a rich background as a medicinal herb. It has been used for centuries in traditional herbal medicine, primarily for its liver-protective properties. Ancient Greek and Roman physicians recognized its value in treating liver and gallbladder disorders.

Does Milk Thistle have any spiritual or ceremonial significance in certain traditions?

Regarding spiritual or ceremonial significance, Milk Thistle does not hold a notable place in specific traditions or rituals. It is primarily appreciated for its medicinal attributes and is not associated with any particular spiritual or ceremonial practices.

Are there any variations in Milk Thistle’s potency based on its geographic origin?

Yes, the potency of Milk Thistle (Silybum marianum) can vary based on its geographic origin. Factors such as climate, soil conditions, and cultivation methods can influence the plant’s active compound content. Generally, Milk Thistle from regions with favorable growing conditions tends to have higher potency.

Does Milk Thistle have a known effect on specific organs or body systems?

Milk Thistle primarily affects the liver. Its active component, silymarin, is known for its hepatoprotective properties, promoting liver health by assisting in detoxification and protecting liver cells from damage. Some studies suggest it may also have potential benefits for the gallbladder and digestive system.

Are there any known interactions of Milk Thistle with commonly prescribed medications?

Milk Thistle may interact with certain medications. It can inhibit the activity of cytochrome P450 enzymes in the liver, which may affect how some drugs are metabolized. Consult your healthcare provider before using Milk Thistle alongside prescription medications, especially those for diabetes, blood clotting, or immunosuppression.

What are the potential benefits and risks of long-term or chronic use of Milk Thistle?

The potential benefits of long-term Milk Thistle use include improved liver function, reduced oxidative stress, and lower risk of liver diseases. However, prolonged use should be monitored by a healthcare professional, as excessive intake may lead to gastrointestinal issues. Long-term safety studies are limited, so it’s essential to use it cautiously.

Is it advisable to cycle on and off Milk Thistle to prevent tolerance or dependence?

Cycling on and off Milk Thistle is not a common practice. Unlike some substances, there is little evidence to suggest that tolerance or dependence develops with Milk Thistle. However, if you plan on using it for an extended period, consult your healthcare provider to establish an appropriate dosing regimen tailored to your specific needs and health goals.

Are there any precautions regarding driving or operating machinery while using Milk Thistle?

While Milk Thistle is generally considered safe for most people, it’s essential to exercise caution when driving or operating heavy machinery, especially if you are experiencing dizziness, fatigue, or any other unusual side effects. These effects are rare, but it’s wise to monitor your response to Milk Thistle before engaging in tasks that require full concentration.

There are no specific dietary restrictions associated with Milk Thistle use. However, maintaining a healthy, balanced diet is always advisable. In some cases, healthcare professionals may recommend dietary changes to address specific health concerns, but these recommendations would be tailored to the individual’s needs rather than being related to Milk Thistle itself.

Does Milk Thistle have any specific recommendations for addressing common side effects?

Common side effects of Milk Thistle are generally mild and include stomach upset or diarrhea in rare instances. To address these side effects, it’s recommended to take Milk Thistle with food or as directed by your healthcare provider. If you experience severe or persistent side effects, consult a healthcare professional for guidance.

Are there any known variations or subspecies of Milk Thistle with different properties?

Milk Thistle, scientifically known as Silybum marianum, is a well-researched herb with documented variations primarily based on the content of its active compound, silymarin. These variations can impact its effectiveness. For instance, Silybum marianum var. album is known for its high silymarin content and is often preferred for medicinal use. However, these variations are usually subtle, and the general properties of Milk Thistle remain consistent.

Does Milk Thistle have any documented cases of misuse or abuse?

There are no documented cases of misuse or abuse of Milk Thistle. It is generally regarded as a safe and well-tolerated herbal supplement when taken as directed. However, it’s crucial to use any herbal remedy responsibly and within recommended dosages. If you have concerns or questions about the use of Milk Thistle, consult a healthcare professional for guidance tailored to your specific needs.

Is Milk Thistle regulated or approved for medicinal use in the United States?

Yes, Milk Thistle is regulated for medicinal use in the United States. It is classified as a dietary supplement by the Food and Drug Administration (FDA) and can be purchased over the counter without a prescription. However, it is essential to choose products from reputable manufacturers to ensure their quality and safety.

Are there any known interactions of Milk Thistle when combined with other medicinal herbs?

Milk Thistle can interact with other medicinal herbs and medications. It may affect the way your body processes certain drugs, particularly those metabolized by the cytochrome P450 enzymes. Some potential interactions include drugs for diabetes, blood thinners, and certain anti-anxiety medications. It’s crucial to consult a healthcare professional before combining Milk Thistle with other herbs or medications to avoid adverse effects.

How does Milk Thistle’s preparation or dosage change for acute versus chronic conditions?

The preparation and dosage of Milk Thistle can vary depending on whether it is used for acute or chronic conditions. For acute conditions, a higher initial dose may be recommended, typically around 200-400 mg of standardized extract per day. For chronic conditions, a lower maintenance dose of 100-200 mg daily may be sufficient. Always follow the dosage instructions on the product label or consult with a healthcare provider for personalized guidance.

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Are there any known withdrawal symptoms when discontinuing the use of Milk Thistle?

There are no known withdrawal symptoms associated with discontinuing the use of Milk Thistle. Since it is not habit-forming, you can stop using it without experiencing withdrawal effects. However, if you were using it to manage a specific health condition, it’s advisable to consult your healthcare provider before discontinuing to ensure a smooth transition.

What are the best supplement brands of Milk Thistle?

The best Milk Thistle supplement brand can vary based on factors such as product quality, concentration of active ingredients (silymarin), and individual preferences. Some reputable brands that produce high-quality Milk Thistle supplements include Nature’s Bounty, Jarrow Formulas, and NOW Foods. However, it’s crucial to do your research and consider factors like third-party testing, ingredient sourcing, and customer reviews to select a brand that aligns with your specific needs and quality standards. Consulting with a healthcare provider before starting any supplement regimen is also advisable to ensure it’s suitable for your health goals and overall well-being.

Article References & Sources

At AncientHerbsWisdom, our content relies on reputable sources, including peer-reviewed studies, to substantiate the information presented in our articles. Our primary objective is to ensure our content is thoroughly fact-checked, maintaining a commitment to accuracy, reliability, and trustworthiness.

  1. Karakuş, A., et al. (2016). Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats.
    https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070
  2. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Biomed Res Int. 2014;2014:941085. doi:10.1155/2014/941085
  3. Kim, J.-L., et al. (2013). Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis.
    https://www.hindawi.com/journals/bmri/2013/919374/
  4. Camini FC, Costa DC. Silymarin: not just another antioxidant. J Basic Clin Physiol Pharmacol. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. doi:10.1515/jbcpp-2019-0206
  5. Kumar, J., et al. (2015). Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer’s model [Abstract].
    https://www.ncbi.nlm.nih.gov/pubmed/25613505
  6. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. The therapeutic potential of milk thistle in diabetes. Rev Diabet Stud. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167
  7. Liu, W., et al. (2015). Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate [Abstract].
    https://www.ncbi.nlm.nih.gov/pubmed/26345246
  8. National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Milk thistle (PDQ®): Health Professional Version.
  9. Lommatzsch, M., et al. (2020). Immune modulation in asthma: Current concepts and future strategies.
    https://www.karger.com/Article/FullText/506651
  10. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database Syst Rev. 2007;2007(4):CD003620. doi:10.1002/14651858.CD003620.pub3
  11. Mamalis, A., et al. (2013). The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro.
    http://jddonline.com/articles/dermatology/S1545961613P0780X
  12. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Res. 2016;2016:5147468. doi:10.1155/2016/5147468
  13. Milk thistle (PDQ) – health professional version. (2021).
    https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq
  14. Seeff LB, Curto TM, Szabo G, et al. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Hepatology. 2008;47(2):605-12. doi:10.1002/hep.22044
  15. Milk thistle (PDQ) – patient version. (2021).
    https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq
  16. Mastron JK, Siveen KS, Sethi G, Bishayee A. Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. Anticancer Drugs. 2015;26(5):475‐486. doi:10.1097/CAD.0000000000000211
  17. Milk thistle. (2021).
    https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/
  18. Gillessen A, Schmidt HH. Silymarin as supportive treatment in liver diseases: a narrative review. Adv Ther. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y
  19. Milk thistle. (2020).
    https://www.nccih.nih.gov/health/milk-thistle
  20. Walsh JA, Jones H, Mallbris L, et al. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Psoriasis (Auckl). 2018;8:65-74. doi:10.2147/PTT.S169333 
  21. Achufusi, T. G. O., et al. (2021). Milk thistle.
    https://www.ncbi.nlm.nih.gov/books/NBK541075/
  22. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytother Res. 2019;33(6):1627-1638. doi:10.1002/ptr.6361
  23. Abenavoli, L., et al. (2010). Milk thistle in liver diseases: Past, present, future [Abstract].
    https://www.ncbi.nlm.nih.gov/pubmed/20564545
  24. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Phytother Res. 2020;34(6):1446-1454. doi:10.1002/ptr.6620
  25. Becker-Schiebe, M., et al. (2011). Topical use of a silymarin-based preparation to prevent radiodermatitis: Results of a prospective study in breast cancer patients.
    https://pubmed.ncbi.nlm.nih.gov/21786113/
  26. National Center for Complementary and Integrative Health. Milk thistle.
  27. Choi, Y. H., et al. (2012). Silibinin attenuates allergic airway inflammation in mice.
    https://www.ncbi.nlm.nih.gov/pubmed/22842463
  28. Fallah M, Davoodvandi A, Nikmanzar S, et al. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Biomed Pharmacother. 2021;142:112024. doi:10.1016/j.biopha.2021
  29. Delmas, D., et al. (2020). Silymarin and cancer: A dual strategy in both chemoprevention and chemosensitivity.
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/
  30. Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and their bioactive phytochemicals for women’s health. Pharmacol Rev. 2016;68(4):1026-1073. doi:10.1124/pr.115.010843
  31. Di Napoli, A., et al. (2021). A comprehensive review of the benefits of Taraxacum officinale on human health.
    https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1
  32. Fried MW, Navarro VJ, Afdhal N, et al. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA. 2012;308(3):274-282. doi:10.1001/jama.2012.8265
  33. Gobalakrishnan, S., et al. (2016). Effect of silybin on lipid profile in hypercholesterolaemic rats.
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/
  34. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Phytomedicine. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010
  35. Guo, Y., et al. (2016). Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice.
    https://www.ncbi.nlm.nih.gov/pubmed/27387273
  36. Dupuis ML, Conti F, Maselli A, et al. The natural agonist of estrogen receptor β silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
  37. Huseini, H. F., et al. (2006). The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: A randomized, double-blind, placebo-controlled, clinical trial [Abstract].
    https://www.ncbi.nlm.nih.gov/pubmed/17072885
  38. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288.
  39. Morowat, M., et al. (2016). Dietary but not in ovo feeding of Silybum marianum extract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilers.
    http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20
  40. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. J Med Assoc Thai. 2014;97 Suppl 11:S31-S40.
  41. Nasaba, E. M., et al. (2020). Immunomodulatory effects of two silymarin isomers in a Balb/c mouse model of allergic asthma.
    https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X
  42. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. J Tradit Complement Med. 2020;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003.
  43. Raina, K., et al. (2016). Silibinin and colorectal cancer chemoprevention: A comprehensive review on mechanisms and efficacy.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/
  44. Siegel, A. B., et al. (2013). Milk thistle: early seeds of potential.
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/
  45. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. J Tradit Complement Med. 2020;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003.
  46. Soliman, N. A., et al. (2015). Taraxacum officinale and Silybum marianum alone or combined orchestrate experimentally induced hepatic steatosis through lipogenecity, glucose tolerance and oxidant/antioxidant status.
    https://www.ajol.info/index.php/ijbcs/article/view/127127
  47. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Eur Endocrinol. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31
  48. Valková, V., et al. (2020). Milk thistle (silybum marianum): A valuable medicinal plant with several therapeutic purposes.
  49. Milk thistle. In: Drugs and Lactation Database (LactMed). National Library of Medicine (US); 2022.
  50. Vostálová, J., et al. (2019). Skin protective activity of silymarin and its flavonolignans.
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/
  51. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887
  52. Wilasrusmee, C., et al. (2002). Immunostimulatory effect of Silybum marianum (milk thistle) extract [Abstract].
    https://www.ncbi.nlm.nih.gov/pubmed/12444368

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