Skullcap Unwrapped: A Detailed 50 Q&A Handbook

This unassuming herb called Skullcap has been utilized for centuries, and its applications span a wide range of physical and mental well-being. To provide a deeper understanding of Skullcap and its various aspects, we’ve compiled a comprehensive 50-question and answer handbook. Whether you’re seeking information about its origins, applications, or potential side effects, this guide aims to shed light on this herbal enigma.

What is Skullcap?

Skullcap, often spelled as “Scullcap,” is a perennial herbaceous plant that belongs to the mint family, Lamiaceae. It is characterized by its small, helmet-shaped flowers and serrated leaves. Skullcap has a long history of use in traditional herbal medicine, primarily for its potential medicinal properties.

What is the scientific name of Skullcap?

The scientific name of Skullcap is Scutellaria, and there are several species within this genus. One of the most commonly used species in herbal remedies is Scutellaria lateriflora, also known as “Blue Skullcap.”

Does Skullcap have other common names?

Skullcap goes by several common names depending on the variety and region. For Scutellaria lateriflora, it is often called “American skullcap,” “mad-dog skullcap,” or “blue skullcap.” Scutellaria baicalensis is sometimes referred to as “Chinese skullcap” or “Baikal skullcap.” These common names help distinguish the two main species.

What is Skullcap’s traditional and modern medicinal use?

Traditional Use: Skullcap has a rich history in traditional herbal medicine. Indigenous cultures in North America, particularly Native American tribes, used Skullcap to treat a range of ailments. It was often employed as a mild sedative and nervine tonic to relieve anxiety, insomnia, and nervous tension.

Modern Use: In modern herbal medicine, Skullcap is still utilized for its potential calming and relaxing effects on the nervous system. It is often recommended for conditions like anxiety, stress, and sleep disorders. Some herbalists and naturopaths also suggest Skullcap for its potential anti-inflammatory and antioxidant properties, though more research is needed to confirm these benefits.

What nutrients (vitamins, minerals, antioxidants, etc.) does Skullcap contain?

Skullcap is not typically valued for its nutrient content like fruits or vegetables. Instead, it is prized for its phytochemical compounds. While the exact composition can vary among species and growing conditions, Skullcap may contain flavonoids (such as baicalin and wogonin), volatile oils, and other bioactive compounds. These components are believed to contribute to its potential therapeutic properties, particularly in promoting relaxation and reducing anxiety.

Are there any potential side effects associated with Skullcap?

Yes, like many herbs, Skullcap (Scutellaria lateriflora) may have potential side effects. Some individuals have reported dizziness, drowsiness, or an upset stomach after using Skullcap. Additionally, there have been rare cases of liver toxicity associated with Skullcap supplements. It’s essential to consult with a healthcare professional before using Skullcap, especially if you’re taking other medications or have underlying health conditions.

What is the recommended dosage for Skullcap?

The recommended dosage for Skullcap can vary depending on the form in which it is taken. For dried Skullcap leaves or as a tea, a common dosage is about 1-2 grams (approximately 1-2 teaspoons) of dried herb infused in hot water, up to three times a day. As a tincture, 2-4 ml (about 40-80 drops) diluted in water can be taken up to three times daily. However, it’s crucial to follow the specific dosing instructions on the product label or consult a healthcare practitioner for personalized guidance.

Is Skullcap safe for pregnant or breastfeeding women?

Skullcap should be used with caution during pregnancy and breastfeeding. While there is limited research on its safety in these situations, it’s generally advisable for pregnant and breastfeeding women to avoid Skullcap due to the lack of comprehensive safety data. Consultation with a healthcare provider is essential before using any herbal remedies during these periods.

Can children safely consume Skullcap?

Skullcap is not typically recommended for children, especially without the guidance of a healthcare professional. Limited research exists on its safety and efficacy in children, so it’s best to err on the side of caution and avoid using Skullcap in children unless specifically advised by a qualified healthcare practitioner.

How should Skullcap be prepared or consumed (e.g., tea, tincture, capsules, tablets)?

Skullcap can be prepared and consumed in various forms, including as a tea, tincture, capsules, or tablets. As a tea, you can steep 1-2 teaspoons of dried Skullcap leaves in hot water for 10-15 minutes before drinking. Tinctures can be taken by diluting the recommended dose in water. Capsules and tablets provide a more standardized and convenient way to consume Skullcap, following the dosage instructions provided on the product label. The choice of preparation depends on your personal preferences and the guidance of a healthcare professional.

Are there any contraindications or health conditions that Skullcap may worsen?

Skullcap is generally considered safe for most individuals when used appropriately. However, there are some contraindications and health conditions to be aware of. It’s advised to avoid Skullcap if you are pregnant or nursing, as its safety in these situations is not well-established. Additionally, individuals with liver disease or a history of seizures should exercise caution, as Skullcap may exacerbate these conditions in some cases.

Where is Skullcap usually sourced or cultivated?

Skullcap, also known as Scutellaria lateriflora, is primarily native to North America and can be found growing in various regions, including the eastern and central United States. It’s often cultivated in gardens for its medicinal properties, but it can also be found growing in the wild in damp, wooded areas.

Is Skullcap legal to possess and use in the United States?

Skullcap is legal to possess and use in the United States. It is not a controlled substance, and it is readily available in various forms, including capsules, tinctures, and dried herbs, at health food stores and online retailers.

Are there any known allergens in Skullcap?

Skullcap is generally considered safe, but like any herbal product, it can potentially cause allergic reactions in some individuals. While Skullcap allergies are rare, it’s wise to exercise caution if you have known allergies to members of the Lamiaceae family, which includes herbs like mint and basil, as Skullcap belongs to the same family.

May Skullcap supplements contain contaminants like pesticides or heavy metals?

Skullcap supplements are subject to regulations by government agencies, such as the FDA, to ensure product safety. However, there is a possibility of contaminants like pesticides or heavy metals in herbal supplements. To minimize this risk, it’s advisable to purchase Skullcap products from reputable manufacturers who adhere to quality control standards and perform rigorous testing for contaminants. Additionally, organic Skullcap products may have a lower risk of pesticide contamination.

Are there any known long-term effects of using Skullcap?

Skullcap, a herb often used for its potential calming and anti-anxiety properties, has a generally favorable safety profile. However, there is limited long-term research on its effects. Some individuals have reported side effects such as dizziness or drowsiness, but these are typically mild and transient. It’s important to use Skullcap supplements in moderation and consult with a healthcare professional if you plan to use them regularly for an extended period. Long-term use may carry risks that are not well-documented, so caution is advisable.

Do Skullcap supplements have a specific shelf life or expiration date?

Like most supplements, Skullcap products should have a labeled expiration date or “best by” date. It’s essential to follow these guidelines to ensure product potency and safety. After the expiration date, the effectiveness of the supplement may decrease, and it could potentially become less safe to use. Storing Skullcap supplements in a cool, dry place, away from direct sunlight, can help prolong their shelf life. Always check the packaging for the expiration date and dispose of any expired products.

What is the best time of day to take Skullcap?

The ideal time to take Skullcap can vary from person to person. Generally, Skullcap is often used to promote relaxation and reduce stress or anxiety. Many people find it beneficial to take Skullcap in the evening or before bedtime to help with sleep or relaxation. However, others may use it during the day to manage stress or anxiety. The best time for you may depend on your individual needs and how Skullcap affects your body. It’s advisable to start with a lower dose and adjust the timing based on your personal response.

Should Skullcap pills be taken with food or on an empty stomach?

Skullcap supplements can be taken with or without food, depending on your preference and tolerance. Some individuals find that taking Skullcap on an empty stomach may lead to faster absorption and potentially stronger effects. However, if Skullcap tends to upset your stomach, you can take it with a small meal or a snack to minimize any discomfort. Experiment to find the method that works best for you, and consult your healthcare provider if you have any concerns or specific dietary requirements.

Are there any dietary restrictions or guidelines while using Skullcap?

There are no specific dietary restrictions associated with Skullcap use. However, it’s essential to maintain a balanced and healthy diet to support overall well-being. Some individuals may choose to avoid caffeine or alcohol while using Skullcap, as these substances can interact with its effects. Additionally, if you have any underlying medical conditions or take other medications, it’s wise to consult with a healthcare professional before incorporating Skullcap into your routine to ensure there are no potential interactions or contraindications. Always prioritize a well-rounded approach to your health, combining appropriate dietary choices with any supplements you may use.

What is the recommended duration of use for Skullcap?

The recommended duration of use for Skullcap can vary depending on individual needs and the specific product you’re using. It’s crucial to follow the dosing instructions on the product label or consult a healthcare professional for personalized guidance. Generally, short-term use is considered safe, but for extended periods, it’s advisable to consult a healthcare provider to monitor any potential side effects.

Is it advisable to consult a healthcare professional before using Skullcap?

Yes, it is advisable to consult a healthcare professional before using Skullcap, especially if you have any underlying health conditions or are taking medications. This precaution ensures that Skullcap won’t interact negatively with your current treatments and that it’s safe for your specific circumstances.

Are there any special precautions for storing Skullcap supplements?

Storing Skullcap supplements correctly is essential to maintain their potency and safety. Typically, it’s best to keep them in a cool, dry place, away from direct sunlight and moisture. Follow the storage recommendations on the product label to ensure the supplements remain effective throughout their shelf life.

How does Skullcap taste, and can it be mixed with other herbs or foods for palatability?

Skullcap is known for having a bitter taste, which may not be pleasant to everyone. You can mix it with other herbs or foods to improve its palatability. Herbal teas or infusions often incorporate Skullcap alongside sweeter or milder-tasting herbs like peppermint or chamomile to create a more enjoyable flavor.

What other supplements work well together with Skullcap?

Skullcap, a herb known for its calming and potential medicinal properties, can be effectively combined with various supplements to enhance its benefits. Here are some supplements that may work well in combination with Skullcap:

• Valerian Root: Valerian Root is often combined with Skullcap for improved sleep and relaxation. This combination can be particularly helpful for individuals dealing with anxiety or sleep disorders.
• Passionflower: Combining Skullcap with Passionflower can provide a powerful natural remedy for anxiety and stress. Together, they may help relax the mind and promote a sense of calm.
• Lemon Balm: Lemon Balm and Skullcap are both known for their soothing properties. This combination can be beneficial for reducing nervousness and promoting relaxation.
• Chamomile: Chamomile is another herb renowned for its calming effects. Combining Chamomile with Skullcap can create a potent natural remedy for stress, anxiety, and sleep disturbances.
• L-Theanine: L-Theanine, commonly found in green tea, can be paired with Skullcap to enhance relaxation without drowsiness. This combination is often used for mental clarity and focus.
• Kava Kava: Kava Kava and Skullcap can create a potent relaxation blend. However, it’s crucial to use Kava Kava cautiously, as it may have potential side effects.
• GABA (Gamma-Aminobutyric Acid): GABA is an inhibitory neurotransmitter that can enhance the calming effects of Skullcap. It’s sometimes used to reduce anxiety and promote relaxation.
• Melatonin: For individuals seeking sleep support, combining Skullcap with melatonin can be beneficial. Melatonin is a hormone that regulates sleep patterns.

Is there any scientific research or clinical evidence supporting Skullcap’s effectiveness?

Yes, there is some scientific research and clinical evidence supporting Skullcap’s effectiveness. Skullcap, scientifically known as Scutellaria lateriflora, has been traditionally used for its potential calming and relaxing properties. Some studies suggest that it may have mild anxiolytic (anxiety-reducing) effects. However, more research is needed to fully understand its mechanisms and effectiveness in different contexts.

Are there any age restrictions for using Skullcap (e.g., suitable for the elderly)?

There are typically no strict age restrictions for using Skullcap. However, it’s important to consider individual factors such as allergies, sensitivities, or underlying health conditions. It’s advisable for elderly individuals to consult with a healthcare professional before using Skullcap or any herbal remedy to ensure it’s safe and appropriate for their specific situation.

Does Scullcap require a specific preparation method, such as decoction or infusion?

Scullcap can be prepared using various methods, including decoction and infusion. Decoction involves boiling the herb in water to extract its active compounds, while infusion is a gentler method that uses hot water to steep the herb. The choice of preparation method may depend on personal preference and the intended use.

Can Skullcap be used topically (externally) in addition to internal consumption?

Skullcap can be used topically (externally) in addition to internal consumption. When used externally, it is often applied as a poultice or infused oil. Topical use is generally considered safe and may be helpful for soothing skin irritations or muscle discomfort. However, it’s essential to dilute Skullcap properly and perform a patch test to check for any adverse reactions before applying it to a larger area of the skin.

Are there any known symptoms of overdose or excessive use of Skullcap?

Excessive use of Skullcap may lead to certain symptoms, including dizziness, drowsiness, or an upset stomach. It’s important to follow recommended dosage guidelines and consult with a healthcare professional or herbalist for personalized advice. If you suspect an overdose or experience severe adverse effects, seek immediate medical attention. It’s always wise to exercise caution and use herbal remedies in moderation.

What is Skullcap’s mode of action within the body?

Skullcap, scientifically known as Scutellaria lateriflora, primarily exerts its mode of action within the body through its bioactive compounds, particularly flavonoids and iridoids. These compounds have demonstrated mild anxiolytic (anxiety-reducing) and sedative properties. Skullcap is believed to interact with neurotransmitters in the brain, such as GABA (gamma-aminobutyric acid), which plays a role in calming the nervous system. However, it’s essential to note that further research is needed to fully understand the precise mechanisms of Skullcap’s action.

Are there any known synergistic effects when Skullcap is combined with specific nutrients?

When it comes to synergistic effects, Skullcap can indeed be combined with specific nutrients or herbs to enhance its benefits. For example, some people combine it with Valerian root or passionflower for a more potent calming effect. These combinations may have a cumulative sedative impact, but it’s advisable to consult a healthcare professional before combining different substances.

Does Skullcap have a distinct aroma or essential oil that may have therapeutic benefits?

Skullcap does have a distinct aroma, often described as slightly minty or earthy. While the aroma itself isn’t known to have therapeutic benefits, the smell can contribute to a sense of relaxation when used in herbal preparations or teas. Some individuals find the scent pleasant and calming.

Are there any cultural or historical uses of Skullcap that should be considered?

Culturally and historically, Skullcap has been used in traditional Native American and early American herbal medicine for its potential calming properties. It was often employed to address nervousness, restlessness, and occasional sleeplessness. It’s essential to respect and acknowledge these historical uses when considering Skullcap.

Does Skullcap have any spiritual or ceremonial significance in certain traditions?

In certain spiritual or ceremonial traditions, Skullcap may hold significance as an herb associated with relaxation and tranquility. However, its role in such contexts would vary widely among different cultures and practices. It’s crucial to research and understand the specific cultural or ceremonial significance of Skullcap in any given tradition before using it in such a manner.

Are there any variations in Skullcap’s potency based on its geographic origin?

Yes, the potency of Skullcap (Scutellaria lateriflora) can vary depending on its geographic origin. Factors like soil composition, climate, and cultivation methods can influence the plant’s chemical composition and, consequently, its potency. For instance, Skullcap grown in different regions may contain varying levels of active compounds, such as flavonoids and polyphenols.

Does Skullcap have a known effect on specific organs or body systems?

Skullcap primarily affects the nervous system. It is known for its calming and soothing properties, making it beneficial for managing anxiety, stress, and insomnia. Skullcap’s effects are attributed to its ability to interact with neurotransmitters like GABA, which help regulate mood and anxiety levels. However, its impact on specific organs or body systems is limited compared to other herbs with more targeted effects.

Are there any known interactions of Skullcap with commonly prescribed medications?

Skullcap has the potential to interact with some commonly prescribed medications. It may enhance the sedative effects of drugs like benzodiazepines and antidepressants, increasing the risk of drowsiness and dizziness. Additionally, it can interact with blood-thinning medications, potentially affecting clotting times. Therefore, it’s essential to consult with a healthcare provider before using Skullcap alongside prescription medications.

What are the potential benefits and risks of long-term or chronic use of Skullcap?

When used responsibly and in moderation, Skullcap is generally considered safe. However, there are potential risks associated with long-term or chronic use. Prolonged use may lead to a reduction in its effectiveness due to tolerance development. Some individuals may also experience side effects like dizziness or digestive issues with prolonged use. It’s advisable to take breaks or seek alternatives to prevent these potential risks.

Is cycling on and off Skullcap advisable to prevent tolerance or dependence?

There’s no conclusive evidence to suggest that cycling on and off Skullcap is necessary to prevent tolerance or dependence. While some individuals may develop tolerance over time, others may not. It’s more important to use Skullcap as needed, in consultation with a healthcare professional, and monitor its effects on an individual basis. If tolerance becomes an issue, discussing alternative herbs or treatments is advisable.

Are there any precautions regarding driving or operating machinery while using Skullcap?

While Skullcap is generally considered safe, it’s important to exercise caution when driving or operating machinery, especially if you’re new to using it. Some individuals may experience drowsiness or dizziness as a side effect, so it’s advisable to gauge your body’s response before engaging in tasks that require full concentration.

Are there any dietary restrictions or lifestyle changes recommended while using Skullcap?

Skullcap does not typically come with specific dietary restrictions. However, maintaining a balanced diet and a healthy lifestyle can complement its potential benefits. Avoiding excessive alcohol or caffeine intake can help mitigate any potential interactions or side effects.

Does Skullcap have any specific recommendations for addressing common side effects?

Common side effects of Skullcap may include drowsiness, dizziness, or an upset stomach in some individuals. If you experience these effects, it’s recommended to reduce the dosage or discontinue use. Additionally, staying well-hydrated and getting adequate rest can aid in managing these side effects.

Are there any known variations or subspecies of Skullcap with different properties?

There are several species of Skullcap, with Scutellaria lateriflora being the most commonly used in herbal remedies. While variations do exist, they generally share similar properties. However, it’s essential to consult with a healthcare professional or herbalist for guidance on specific subspecies, as their effects may vary.

Does Skullcap have any documented cases of misuse or abuse?

Skullcap is not typically associated with misuse or abuse. It is regarded as a safe herbal remedy when used responsibly and in moderation. However, as with any substance, using it excessively or inappropriately can potentially lead to adverse effects. It’s advisable to follow recommended dosages and consult with a healthcare provider for personalized guidance if needed.

Is Skullcap regulated or approved for medicinal use in the United States?

Skullcap, scientifically known as Scutellaria lateriflora, is not regulated or approved for medicinal use by the United States Food and Drug Administration (FDA). It is classified as a dietary supplement, and its safety and efficacy have not been extensively evaluated through the FDA’s rigorous drug approval process.

Are there any known interactions of Scullcap when combined with other medicinal herbs?

Skullcap can interact with certain medicinal herbs and medications. It’s important to exercise caution when combining it with other herbs or drugs that have sedative or central nervous system depressant effects, as it may potentiate these effects. Some herbs and drugs to be mindful of include valerian, kava, and prescription medications like benzodiazepines and barbiturates.

How does Skullcap’s preparation or dosage change for acute versus chronic conditions?

The preparation and dosage of Scullcap can vary based on whether it is being used for acute or chronic conditions. For acute conditions such as anxiety or occasional sleeplessness, a tincture or infusion (tea) of Skullcap can be taken in smaller, short-term doses. For chronic conditions, a standardized extract or capsule form may be more appropriate, and dosages should be discussed with a healthcare professional.

Are there any known withdrawal symptoms when discontinuing the use of Skullcap?

There are no well-documented withdrawal symptoms associated with discontinuing the use of Skullcap. However, as with any herbal remedy, abrupt cessation after prolonged use may result in a temporary return of the symptoms it was initially used to address. It’s advisable to taper off its use gradually under the guidance of a healthcare practitioner if you’ve been using it for an extended period.

What are the best supplement brands of Skullcap?

When looking for skullcap supplements, it’s essential to choose reputable brands that adhere to quality and safety standards. Some well-regarded supplement brands include Nature’s Way, Gaia Herbs, and Herb Pharm. However, it’s advisable to consult with a healthcare professional before starting any new herbal supplement regimen to ensure it’s appropriate for your individual health needs.

Article References & Sources

At AncientHerbsWisdom, our content relies on reputable sources, including peer-reviewed studies, to substantiate the information presented in our articles. Our primary objective is to ensure that our content is thoroughly fact-checked, maintaining a commitment to accuracy, reliability, and trustworthiness.

1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Skullcap. [Updated 2020 Mar 28]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548757/ 
2. MacGregor FB, Abernethy VE, Dahabra S, Cobden I, Hayes PC. Hepatotoxicity of herbal remedies. BMJ. 1989;299:1156–7. https://pubmed.ncbi.nlm.nih.gov/2513032 
3. Dinda B, Dinda S, DasSharma S, Banik R, Chakraborty A, Dinda M. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur J Med Chem. 2017;131:68-80. doi:10.1016/j.ejmech.2017.03.004
4. Sajeev A, Hegde M, Daimary UD, et al. Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment. Phytomedicine. 2022;105:154369. doi:10.1016/j.phymed.2022.154369
5. Shih HC, Yang LL. Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. Pharm Biol. 2012;50(6):760-765. doi:10.3109/13880209.2011.631930
6. Pan L, Cho KS, Yi I, To CH, Chen DF, Do CW. Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina. Oxid Med Cell Longev. 2021;2021:8377362. Published 2021 Jun 29. doi:10.1155/2021/8377362
7. Cheng YY, Hsieh CH, Tsai TH. Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. J Food Drug Anal. 2018;26(2S):S88-S95. doi:10.1016/j.jfda.2018.01.003
8. Mao D, He Z, Li L, et al. Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis. J Healthc Eng. 2022;2022:3594210. Published 2022 Apr 11. doi:10.1155/2022/3594210
9. Zhang C, Wang N, Tan HY, Guo W, Li S, Feng Y. Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine. Integr Cancer Ther. 2018;17(3):582-601. doi:10.1177/1534735418775828
10. Idrees M, Khan S, Memon NH, Zhang Z. Effect of the Phytochemical Agents against the SARS-CoV and Some of them Selected for Application to COVID-19: A Mini-Review. Curr Pharm Biotechnol. 2021;22(4):444-450. doi:10.2174/1389201021666200703201458
11. Li M, Shi A, Pang H, et al. Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects. J Ethnopharmacol. 2014;156:210-215. doi:10.1016/j.jep.2014.08.031
12. Yang JY, Li M, Zhang CL, Liu D. Pharmacological properties of baicalin on liver diseases: a narrative review. Pharmacol Rep. 2021;73(5):1230-1239. doi:10.1007/s43440-021-00227-1
13. Ming J, Zhuoneng L, Guangxun Z. Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. Complement Ther Med. 2018;38:11-18. doi:10.1016/j.ctim.2018.03.010
14. Wang X, Xie L, Long J, et al. Therapeutic effect of baicalin on inflammatory bowel disease: A review. J Ethnopharmacol. 2022;283:114749. doi:10.1016/j.jep.2021.114749
15. Miskelly FG, Goodyer LI. Hepatic and pulmonary complications of herbal medicines. Postgrad Med J. 1992;68:935. https://pubmed.ncbi.nlm.nih.gov/1494520 
16. Zhou X, Fu L, Wang P, Yang L, Zhu X, Li CG. Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs: Insights from experimental studies, mechanistic actions to clinical applications. Biomed Pharmacother. 2021;138:111445. doi:10.1016/j.biopha.2021.111445
17. Banik K, Khatoon E, Harsha C, et al. Wogonin and its analogs for the prevention and treatment of cancer: A systematic review. Phytother Res. 2022;36(5):1854-1883. doi:10.1002/ptr.7386
18. Zhang C, Wang N, Tan HY, Guo W, Li S, Feng Y. Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine. Integr Cancer Ther. 2018;17(3):582-601. doi:10.1177/1534735418775828
19. Yingrui W, Zheng L, Guoyan L, Hongjie W. Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications. Biomed Pharmacother. 2022;148:112690. doi:10.1016/j.biopha.2022.112690
20. Li X, Liu J, Fang Y, et al. Potential Therapeutic Mechanism of Scutellaria baicalensis Georgi against Ankylosing Spondylitis Based on a Comprehensive Pharmacological Model. Biomed Res Int. 2022;2022:9887012. Published 2022 Dec 21. doi:10.1155/2022/9887012
21. Baradaran Rahimi V, Askari VR, Hosseinzadeh H. Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review. Phytother Res. 2021;35(7):3558-3574. doi:10.1002/ptr.7046
22. Huang D, Liu J, Zong RK, Wan L. Zhongguo Zhong Yao Za Zhi. 2020;45(2):451-456. doi:10.19540/j.cnki.cjcmm.20190619.501
23. Wang ZL, Wang S, Kuang Y, Hu ZM, Qiao X, Ye M. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Biol. 2018;56(1):465-484. doi:10.1080/13880209.2018.1492620
24. Dong R, Li L, Gao H, et al. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. J Ethnopharmacol. 2021;274:114052. doi:10.1016/j.jep.2021.114052
25. Alsharairi NA. Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma. Int J Environ Res Public Health. 2021;18(10):5243. Published 2021 May 14. doi:10.3390/ijerph18105243
26. Fang DN, Zheng CW, Ma YL. Effectiveness of Scutellaria baicalensis Georgi root in pregnancy-related diseases: A review. J Integr Med. 2023;21(1):17-25. doi:10.1016/j.joim.2022.09.005
27. National Center for Biotechnology Information. PubChem Substance Record for SID 135316960, Scutellaria baicalensis.
28. Zhang P, Hölscher C, Ma X. Therapeutic potential of flavonoids in spinal cord injury. Rev Neurosci. 2017;28(1):87-101. doi:10.1515/revneuro-2016-0053
29. Zhao Q, Chen XY, Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Sci Bull (Beijing). 2016;61(18):1391-1398. doi:10.1007/s11434-016-1136-5

Valuable Resources

• Skullcap: Everything You Need to Know About It
• Skullcap Information | Mount Sinai – New York
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