Unlocking Valerian’s Secrets: A Comprehensive 50 Q&A Guide

Delving into the world of natural remedies and holistic wellness, this comprehensive Q&A guide aims to shed light on the many facets of Valerian, a plant renowned for its potential health benefits. From its historical uses to its modern applications, this article serves as a valuable resource for those seeking to understand the secrets held within this ancient herb.

Valerian: 50 Questions & Answers

What is Valerian?

Valerian is a perennial flowering plant native to Europe and Asia. It’s renowned for its therapeutic properties, primarily as a natural remedy for sleep disorders and anxiety. Valerian’s root is the most commonly used part for its medicinal benefits, particularly in herbal supplements and teas.

What is the scientific name of Valerian?

The scientific name of Valerian is Valeriana officinalis. This botanical name is used to classify the plant in the Valerianaceae family.

Does Valerian have other common names?

Yes, Valerian is known by various common names, including All-Heal, Amantilla, Setewale Capon’s Tail, Garden Heliotrope, and St. George’s Herb. These names might vary by region or culture.

What is Valerian’s traditional and modern medicinal use?

Traditionally, Valerian has a rich history as a medicinal herb dating back to ancient Greece and Rome. It was used to treat a range of ailments, including insomnia, nervousness, and digestive issues. In modern times, Valerian remains popular for its calming and sleep-inducing effects. It’s often used as a natural remedy for insomnia, anxiety, and stress. Valerian is available in various forms, such as capsules, extracts, and teas, making it accessible to those seeking its therapeutic benefits.

What nutrients (vitamins, minerals, antioxidants, etc.) does Valerian contain?

Valerian’s nutritional profile is relatively modest, as its primary value lies in its bioactive compounds rather than essential nutrients like vitamins or minerals. It contains several compounds, such as valerenic acid, isovaleric acid, and volatile oils, which are believed to contribute to its sedative and anxiolytic (anxiety-reducing) effects. While it may not be a significant source of vitamins, minerals, or antioxidants, Valerian’s herbal constituents make it a valuable option for those seeking natural remedies for sleep and anxiety issues.

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Are there any potential side effects associated with Valerian?

Valerian is generally considered safe when used as directed. However, some people may experience mild side effects, including dizziness, headache, upset stomach, dry mouth, and daytime drowsiness. These side effects are usually mild and tend to go away on their own. Rarely, individuals may have an allergic reaction to Valerian, which could manifest as itching, rash, or difficulty breathing. If you experience severe or persistent side effects, it’s essential to consult a healthcare professional.

The recommended dosage of Valerian can vary depending on the form in which it’s taken and individual factors such as age and overall health. Typically, for adults seeking relief from anxiety or sleep issues, a standard dose ranges from 300 to 600 milligrams of Valerian root extract or powder, taken 30 minutes to two hours before bedtime. It’s advisable to start with a lower dose and gradually increase it if needed. Always follow the product label instructions or consult a healthcare provider for personalized guidance.

Is Valerian safe for pregnant or breastfeeding women?

While Valerian has a long history of use as a natural remedy for anxiety and sleep disorders, its safety during pregnancy and breastfeeding is not well-established. Pregnant and breastfeeding women should exercise caution and consult their healthcare provider before using Valerian. It’s essential to weigh the potential benefits against the possible risks and consider alternative approaches to manage anxiety or sleep issues during these periods.

Can children safely consume Valerian?

Valerian is generally not recommended for children without the guidance of a healthcare professional. The safety and appropriate dosage for children can vary significantly based on age, weight, and specific health conditions. It’s crucial to consult with a pediatrician or healthcare provider before giving Valerian to a child to ensure it is safe and appropriate for their individual needs.

How should Valerian be prepared or consumed (e.g., tea, tincture, capsules, tablets)?

Valerian is available in various forms, including tea, tinctures, capsules, and tablets. The choice of preparation depends on personal preference and the desired effects. Valerian tea is made by steeping dried Valerian root in hot water, while tinctures are concentrated liquid extracts. Capsules and tablets offer convenient dosing options. Follow the recommended dosage instructions provided on the product label for the specific form of Valerian you choose. The effects may vary slightly between forms, so it’s a matter of individual preference and convenience.

Are there any contraindications or health conditions that may be worsened by Valerian?

Valerian is generally considered safe for most people when used as directed. However, there are certain contraindications and health conditions to be aware of. Individuals with liver disease, pregnant or nursing women, and those taking sedative medications should consult a healthcare professional before using Valerian. It may interact with these conditions or medications, potentially worsening them.

Where is Valerian usually sourced or cultivated?

Valerian (Valeriana officinalis) is native to Europe and parts of Asia, but it’s also cultivated in North America. The plant’s root is the primary part used for its medicinal properties. Commercially, Valerian is sourced from both wild-harvested and cultivated plants, with Germany and Eastern Europe being major producers.

Valerian is legal to possess and use in the United States. It is categorized as a dietary supplement, and its sale is regulated by the Food and Drug Administration (FDA). However, the quality and purity of Valerian supplements may vary between brands, so it’s advisable to choose products from reputable manufacturers.

Are there any known allergens in Valerian?

Valerian itself is not a common allergen, and allergic reactions are rare. However, some individuals may experience side effects like dizziness, headaches, or upset stomach when taking Valerian supplements. If you have known allergies to plants in the Valerian family (Valerianaceae) or other herbs, it’s essential to exercise caution and monitor for any adverse reactions.

May Valerian supplements contain contaminants like pesticides or heavy metals?

Valerian supplements may contain trace amounts of contaminants like pesticides or heavy metals, depending on the source and processing methods. To ensure product safety, consumers should opt for Valerian supplements from reputable brands that adhere to quality and safety standards. Third-party testing and certifications can also help verify the purity and quality of Valerian products.

Are there any known long-term effects of using Valerian?

Valerian is generally considered safe for short-term use, typically up to a few months. However, there isn’t enough long-term research to definitively confirm its safety beyond that period. Some individuals may experience side effects such as dizziness, drowsiness, or gastrointestinal discomfort. Prolonged use may lead to tolerance, where the effectiveness decreases over time. It’s important to consult a healthcare professional if you intend to use Valerian for an extended period or have concerns about its long-term effects.

Do Valerian supplements have a specific shelf life or expiration date?

Valerian supplements, like most herbal products, have a shelf life. The expiration date can vary depending on the manufacturer and the formulation of the product. Generally, Valerian supplements can last for 1-2 years if stored properly in a cool, dry place away from direct sunlight. However, it’s crucial to check the label for the specific expiration date provided by the manufacturer. Using Valerian supplements beyond their expiration date may reduce their potency and effectiveness.

What is the best time of day to take Valerian?

The ideal time to take Valerian can vary from person to person based on their sleep patterns and the reason for using it. Many people take Valerian supplements about 30 minutes to an hour before bedtime to help with sleep. However, if you’re using Valerian for anxiety or stress during the day, you can take it as needed. It’s essential to start with a low dose and adjust based on your individual response.

Should Valerian pills be taken with food or on an empty stomach?

Valerian can be taken with or without food, depending on your preference and how it affects your stomach. Some people find that taking it with a light snack or meal helps reduce the risk of gastrointestinal discomfort. Others prefer to take it on an empty stomach for faster absorption. Experiment to see which method works best for you, but always follow the dosing instructions on the product label.

Are there any dietary restrictions or guidelines while using Valerian?

There are no specific dietary restrictions associated with Valerian use. However, it’s essential to avoid alcohol and other substances that can cause drowsiness or interact with Valerian’s effects. If you have underlying medical conditions or take prescription medications, consult your healthcare provider before using Valerian to ensure there are no potential interactions or contraindications. Additionally, maintaining a balanced diet and healthy lifestyle can complement the benefits of Valerian in managing stress and sleep-related issues.

The recommended duration of use for Valerian can vary depending on individual needs and the specific product you are using. In general, Valerian is considered safe for short-term use, typically up to four to six weeks. If you plan to use it for a longer duration, it’s advisable to consult with a healthcare professional for guidance.

Is it advisable to consult a healthcare professional before using Valerian?

It is generally advisable to consult a healthcare professional before using Valerian, especially if you are pregnant, nursing, taking medication, or have underlying health conditions. They can help you determine the appropriate dosage and ensure it won’t interact with any other medications or supplements you may be taking.

Are there any special precautions for storing Valerian supplements?

When it comes to storing Valerian supplements, it’s crucial to keep them in a cool, dry place, away from direct sunlight and moisture. Proper storage helps maintain the potency and effectiveness of the product. Always follow the storage instructions provided on the product’s label.

How does Valerian taste, and can it be mixed with other herbs or foods for palatability?

Valerian has a strong, earthy, and somewhat pungent odor, which some people find unpleasant. As for its taste, it can be bitter and somewhat spicy. To make it more palatable, you can mix Valerian with other herbs or foods, such as honey or herbal tea blends. This can help mask the taste and make it more enjoyable to consume.

What other supplements work well together with Valerian?

Valerian root is a popular herbal supplement known for its potential to promote relaxation, reduce anxiety, and improve sleep quality. It can be combined with various other supplements to address specific health goals. Here are some supplements that can work well with Valerian:

  • Melatonin: Combining Valerian with melatonin can be effective for individuals with sleep issues. Valerian may help with sleep onset and melatonin can regulate the sleep-wake cycle.
  • L-Theanine: L-Theanine, commonly found in green tea, can enhance the calming effects of Valerian without causing drowsiness. This combination may be used for anxiety and relaxation.
  • Passionflower: Passionflower and Valerian are both natural sedatives. When used together, they can have a synergistic effect in promoting better sleep and reducing anxiety.
  • Lemon Balm: Lemon Balm is an herb known for its calming properties. Combining it with Valerian can create a soothing blend that helps with relaxation and reducing restlessness.
  • Chamomile: Chamomile is another herb with natural calming properties. When taken alongside Valerian, it can be particularly useful for individuals looking to manage anxiety and improve sleep.
  • Magnesium: Magnesium is a mineral that plays a role in relaxation and sleep regulation. When used with Valerian, it can support deeper and more restful sleep.
  • GABA (Gamma-Aminobutyric Acid): GABA is an amino acid that acts as a neurotransmitter with calming effects. Combining Valerian with GABA can further enhance relaxation and stress reduction.
  • 5-HTP (5-Hydroxytryptophan): 5-HTP is a precursor to serotonin, a neurotransmitter that plays a role in mood and sleep. When used with Valerian, it can support a more balanced mood and better sleep.

Is there any scientific research or clinical evidence supporting Valerian’s effectiveness?

Yes, scientific research and clinical evidence is supporting Valerian’s effectiveness as a natural remedy for sleep disorders and anxiety. Numerous studies have indicated its potential to improve sleep quality and reduce the time it takes to fall asleep. Valerian’s active compounds, such as valerenic acid, appear to interact with GABA receptors in the brain, promoting relaxation and sleep.

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Are there any age restrictions for using Valerian (e.g., suitable for the elderly)?

Valerian is generally considered safe for use by individuals of various age groups, including the elderly. However, it’s essential to consult with a healthcare professional, especially if you are taking other medications or have specific health concerns. They can provide personalized guidance based on your circumstances.

Does Valerian require a specific preparation method, such as decoction or infusion?

Valerian can be prepared in various ways, such as in the form of capsules, tinctures, or teas. There’s no specific preparation method like decoction or infusion necessary. The choice of preparation depends on personal preference and convenience. Follow the instructions provided on the product label or consult with a healthcare provider for dosing recommendations.

Can Valerian be used topically (externally) in addition to internal consumption?

While Valerian is primarily used for internal consumption, it is generally not used topically or externally. Its effects are primarily achieved through ingestion, where the active compounds interact with the central nervous system to induce relaxation and sleep. There is limited evidence to suggest any benefit from topical application.

Are there any known symptoms of overdose or excessive use of Valerian?

Excessive use or overdose of Valerian may lead to side effects such as dizziness, headache, upset stomach, and drowsiness. However, Valerian is not known to be toxic or life-threatening even in higher doses. It’s crucial to follow the recommended dosage instructions on the product label or as advised by a healthcare professional to avoid potential adverse effects. If you suspect an overdose or experience severe side effects, seek medical attention promptly.

What is Valerian’s mode of action within the body?

Valerian’s mode of action primarily revolves around its interaction with the GABA (gamma-aminobutyric acid) system in the brain. It contains compounds like valerenic acid that enhance the activity of GABA, a neurotransmitter known for its calming and relaxing effects. By increasing GABA levels, Valerian helps reduce anxiety and promote sleep. Additionally, Valerian may inhibit the reuptake of GABA, making it more available in the brain.

Are there any known synergistic effects when Valerian is combined with specific nutrients?

Valerian is often combined with other herbs and nutrients to enhance its effects. For example, it may work synergistically with hops, lemon balm, or passionflower to improve sleep quality and duration. Some individuals also find benefits when combining Valerian with magnesium, as magnesium supports relaxation and muscle tension reduction. However, it’s essential to consult a healthcare professional before combining Valerian with other supplements, especially if you have specific health concerns or are taking medications.

Does Valerian have a distinct aroma or essential oil that may have therapeutic benefits?

Yes, Valerian has a distinct, pungent aroma due to its essential oil content, primarily valerenic acid. While the scent is not particularly pleasant to some, it has been used historically for its potential therapeutic benefits. Valerian essential oil is sometimes applied topically to alleviate muscle tension and ease anxiety. However, its strong odor may limit its popularity as an aromatherapy choice.

Are there any cultural or historical uses of Valerian that should be considered?

Valerian has a rich history of use dating back centuries. It was used in ancient Greece and Rome for various ailments, including insomnia and nervousness. In medieval Europe, it gained popularity as a remedy for anxiety and as a sleep aid. Valerian’s name even derives from the Latin word “valere,” meaning “to be healthy” or “to be strong.” These historical uses offer insights into its traditional reputation as a calming and healing herb.

Does Valerian have any spiritual or ceremonial significance in certain traditions?

Valerian does not have widespread spiritual or ceremonial significance in established religious traditions. However, it may have been used in traditional herbalism and folk remedies for its calming properties. In some cultures, herbs like Valerian were considered sacred for their perceived ability to restore balance and well-being. While not a central element in any specific spiritual practice, Valerian’s historical use reflects its role in promoting mental and physical relaxation.

Are there any variations in Valerian’s potency based on its geographic origin?

Yes, there can be variations in Valerian’s potency based on its geographic origin. Valerian’s active compounds, like valerenic acid, may vary in concentration depending on the region where it’s grown. Some studies suggest that Valerian from certain areas may exhibit higher or lower levels of these compounds, potentially affecting its effectiveness.

Does Valerian have a known effect on specific organs or body systems?

Valerian primarily affects the central nervous system, specifically targeting the GABA (gamma-aminobutyric acid) receptors. This interaction leads to a calming and sedative effect, making it beneficial for alleviating anxiety, improving sleep, and reducing stress. However, Valerian’s effects are not organ-specific; it acts systemically to promote relaxation.

Are there any known interactions of Valerian with commonly prescribed medications?

Valerian can interact with some commonly prescribed medications. Notably, it may enhance the effects of medications that depress the central nervous system, such as sedatives, antidepressants, and anti-anxiety drugs. Combining Valerian with these medications could potentially lead to excessive sedation or drowsiness. It’s crucial to consult with a healthcare professional before using Valerian alongside prescription drugs.

What are the potential benefits and risks of long-term or chronic use of Valerian?

The potential benefits of long-term Valerian use include improved sleep quality, reduced anxiety, and stress relief. However, the risks of chronic use are relatively low compared to some other substances. Valerian is generally considered safe when used as directed, but some individuals may experience side effects like dizziness or gastrointestinal issues. Prolonged use may lead to tolerance, where higher doses are needed for the same effect, but dependence or withdrawal symptoms are rare.

Is it advisable to cycle on and off Valerian to prevent tolerance or dependence?

It’s not necessary to cycle on and off Valerian to prevent tolerance or dependence in most cases. Unlike certain medications or substances, Valerian does not typically lead to significant tolerance or addiction. However, if you find that its effectiveness decreases over time, it’s advisable to consult with a healthcare provider to explore alternative strategies for managing your sleep or anxiety concerns. Regular breaks from Valerian may be considered on an individual basis but this is not standard practice for most users.

Are there any precautions regarding driving or operating machinery while using Valerian?

Valerian is generally considered safe when used as directed for its intended purpose, which is primarily to promote relaxation and sleep. However, it can cause drowsiness in some individuals, especially when taken in larger doses. As a precaution, it’s advisable to avoid driving or operating heavy machinery after taking Valerian until you are certain of how it affects you personally. If you experience drowsiness or impaired coordination, it’s best to refrain from such activities.

There are no specific dietary restrictions associated with Valerian use. However, it’s a good practice to avoid consuming alcohol while using Valerian as it can intensify the sedative effects and potentially lead to excessive drowsiness. Additionally, maintaining a healthy lifestyle, including regular exercise and a balanced diet, can complement the effects of Valerian in promoting overall well-being and better sleep.

Does Valerian have any specific recommendations for addressing common side effects?

Valerian is generally considered safe when used as directed. However, some individuals may experience mild side effects, such as dizziness, upset stomach, or headaches. If you encounter these symptoms, it’s advisable to reduce the dosage or discontinue use. It’s crucial to follow recommended dosages provided by a healthcare professional or mentioned on the product label. Additionally, consider consulting with a healthcare provider if you experience severe or persistent side effects.

Are there any known variations or subspecies of Valerian with different properties?

Valeriana officinalis is the most commonly used species of Valerian. However, there are other species with varying chemical compositions that may have slightly different effects. For example, Valeriana edulis is used in traditional medicine in some regions. It’s important to note that the specific properties and safety profiles of these variations may differ, so it’s advisable to consult with an herbalist or healthcare provider if considering alternatives to Valeriana officinalis.

Does Valerian have any documented cases of misuse or abuse?

Valerian is not considered to have a high potential for misuse or abuse. It’s not known to be habit-forming or addictive. However, individuals should use Valerian as directed and avoid exceeding recommended doses. Misuse, such as taking excessively large amounts, may lead to unwanted side effects or interactions with other medications or substances. If you suspect misuse or experience adverse effects, seek medical advice promptly.

Is Valerian regulated or approved for medicinal use in the United States?

In the United States, Valerian is classified as a dietary supplement and is regulated by the FDA (Food and Drug Administration). It is not approved as a prescription medication for specific medical conditions. Consequently, manufacturers are responsible for ensuring the safety and labeling accuracy of Valerian products. It’s essential to choose products from reputable manufacturers that comply with FDA regulations.

Are there any known interactions of Valerian when combined with other medicinal herbs?

Valerian has the potential to interact with other herbs or medications, especially those with sedative effects. It is crucial to consult with a healthcare provider or herbalist before combining Valerian with other herbs or supplements, especially if you are taking medications. Common interactions may occur with herbs like St. John’s Wort, and kava, or medications such as sedatives, antidepressants, or anti-anxiety drugs. Monitoring for side effects and adjusting dosages, if necessary, should be done under professional guidance.

How does Valerian’s preparation or dosage change for acute versus chronic conditions?

The preparation and dosage of Valerian can vary depending on whether it’s used for acute or chronic conditions. For acute situations, such as occasional insomnia or anxiety, a lower dose (typically 300-600 mg) of Valerian extract or tea taken 30 minutes to an hour before bedtime or when needed may be effective.

For chronic conditions, like ongoing anxiety or sleep disorders, it’s best to consult with a healthcare provider for personalized guidance. They may recommend higher doses (up to 900 mg) of Valerian extract in divided doses throughout the day. The duration of use for chronic conditions should also be discussed with a healthcare professional to avoid potential tolerance or dependence issues.

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Are there any known withdrawal symptoms when discontinuing the use of Valerian?

Valerian is generally considered safe for most people and does not typically lead to withdrawal symptoms when discontinued. However, in rare cases, some individuals might experience mild withdrawal effects, such as insomnia, nervousness, or headaches, especially if they have been using high doses or taking Valerian for an extended period. These symptoms are usually short-lived and relatively mild compared to withdrawal from substances like opioids or benzodiazepines.

What are the best supplement brands of Valerian?

Valerian is available in various forms, including capsules, tinctures, and teas. When looking for reputable supplement brands, it’s important to choose products from established companies that adhere to quality and safety standards. Some well-known brands that offer Valerian supplements include Nature’s Way, Gaia Herbs, and Solaray. However, it’s essential to consult with a healthcare professional before starting any new supplement regimen to ensure it’s appropriate for your individual needs and health status.

Article References & Sources

At AncientHerbsWisdom, our content relies on reputable sources, including peer-reviewed studies, to substantiate the information presented in our articles. Our primary objective is to ensure that our content is thoroughly fact-checked, maintaining a commitment to accuracy, reliability, and trustworthiness.

  1. Valerian – Fact sheet for health professionals. (2013, March 15)
    https://ods.od.nih.gov/factsheets/Valerian-HealthProfessional/#en23
  2. National Center for Complementary and Integrative Health. Valerian.
  3. Getting to know the valerian plant. (2015, June 24)
    https://theherbalacademy.com/getting-to-know-the-valerian-plant/
  4. Kenda M, Glavač NK, Nagy M, Sollner Dolenc M, On Behalf Of The Oemonom. Herbal products used in menopause and for gynecological disorders. Molecules. 2021;26(24):7421. Published 2021 Dec 8. doi:10.3390/molecules26247421
  5. Palmieri, G., Contaldi, P., & Fogliame, G. (2017, May 26). Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nature and Science of Sleep, 9, 163-169
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457154/
  6. Valerian. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
  7. Shi, Y., Dong, J.-W., Zhao, J.-H., Tang, L.-N., & Zhang, J.-J. (2014). Herbal insomnia medications that target GABAergic systems: A review of the psychopharmacological evidence. Current neuropharmacology, 12(3), 289-302
    https://pdfs.semanticscholar.org/e983/5f2890559082866071ff40480c46d51b5059.pdf
  8. Bruni O, Ferini-Strambi L, Giacomoni E, Pellegrino P. Herbal remedies and their possible effect on the GABAergic system and sleep. Nutrients. 2021;13(2):530. doi:10.3390/nu13020530
  9. Jackson PA, Forster J, Khan J, et al. Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: a randomized, double-blind, parallel group, clinical trial. Front Nutr. 2021;7:606124. doi:10.3389/fnut.2020.606124
  10. Tammadon MR, Nobahar M, Hydarinia-Naieni Z, Ebrahimian A, Ghorbani R, Vafaei AA. The effects of valerian on sleep quality, depression, and state anxiety in hemodialysis patients: A randomized, double-blind, crossover clinical trial. Oman Med J. 2021;36(2):e255. doi:10.5001/omj.2021.56
  11. Barton, D. L., Atherton, P. J., Bauer, B. A., Moore Jr, D. F., Mattar, B. I., LaVasseur, B. I., … Loprinzi, C. L. (2011, January-February). The use of valeriana officinalis (valerian) in improving sleep in patients who are undergoing treatment for cancer: A phase III randomized, placebo-controlled, double-blind study: NCCTG Trial, N01C5. The journal of supportive oncology, 9(1), 24-31
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052692/
  12. Zare Elmi HK, Gholami M, Saki M, Ebrahimzadeh F. Efficacy of valerian extract on sleep quality after coronary artery bypass graft surgery: A triple-blind randomized controlled trial. Chin J Integr Med. 2021;27(1):7-15. doi:10.1007/s11655-020-2727-1
  13. Lakhan, S. E., & Vieira, K. F. (2010, October 7). Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutrition journal, 9(1), 42
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959081/
  14. Winter AS, Haverkamp C, Gratzke C, Huber R, Lederer AK. Valerian and postoperative sleep: A retrospective cohort analysis of gynecological, urologic and general surgical patients. Sleep. 2022;zsac122. doi:10.1093/sleep/zsac122
  15. Bent, S., Padula, A., Moore, D., Patterson, M., & Mehling, W. (2006, December). Valerian for sleep: A systematic review and meta-analysis. The American journal of medicine, 119(12), 1005-1012
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394901/
  16. National Institutes of Health, National Center for Biotechnology Information: Drugs and Lactation Database (LactMed). Valerian.
  17. Mehrpooya M, Rabiee S, Larki-Harchegani A, et al. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot. 2018;7:36. Published 2018 Mar 1. doi:10.4103/jehp.jehp_81_17.
  18. Kelber O, Nieber K, Kraft K. Valerian: no evidence for clinically relevant interactions. Evid Based Complement Alternat Med. 2014;2014:879396. doi:10.1155/2014/879396.
  19. Guadagna S, Barattini DF, Rosu S, Ferini-Strambi L. Plant extracts for sleep disturbances: A systematic review. Evid Based Complement Alternat Med. 2020;2020:3792390. doi:10.1155/2020/3792390
  20. Lillehei AS, Halcón LL, Savik K, Reis R. Effect of Inhaled Lavender and Sleep Hygiene on Self-Reported Sleep Issues: A Randomized Controlled Trial. J Altern Complement Med. 2015;21(7):430-438. doi:10.1089/acm.2014.0327.
  21. Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res. 2013;12(1):217-222.
  22. National Institutes of Health, Office of Dietary Supplements. Valerian.
  23. Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders-A systematic review and meta-analysis. J Evid Based Integr Med. 2020;25:2515690X20967323. doi:10.1177/2515690X20967323
  24. Baek JH, Nierenberg AA, Kinrys G. Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Aust N Z J Psychiatry. 2014;48(8):705-715. doi:10.1177/0004867414539198
  25. Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders-A systematic review and meta-analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. doi:10.1177/2515690X20967323
  26. Becker, A., Felgentreff, F., Schröder, H., Meier, B., & Brattström, A. (2014, July 28). The anxiolytic effects of a Valerian extract is based on Valerenic acid. BMC complementary and alternative medicine, 14(1), 267
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122768/
  27. Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res. 2018;32(1):3-18. doi:10.1002/ptr.5940

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